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Inflammation - Institutleder til klinisk medicin

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Leukotrien antagonisme<br />

Arachidonsyre<br />

÷<br />

5-HPETE<br />

5-LO inhibitorer (ex.Zileuton)<br />

FLAP inhibitorer<br />

LTA 4<br />

LTB 4<br />

BLTR - chemotaxi (neutrofil)<br />

"respiratory burst"<br />

LTC 4<br />

LTD 4<br />

LTE 4<br />

CysLT 1<br />

-receptor - eosinofil chemotaxi<br />

÷<br />

bronchokonstriktion<br />

CysLT 1 -receptor antagonister<br />

(eg Zafir-, Pran-, Montelukast)<br />

CysLT 2<br />

-receptor<br />

Eicosanoider<br />

- <strong>klinisk</strong>/terapeutiske relationer 1)<br />

Cardiovaskulært<br />

Ductus arteriosus<br />

Antitrombotisk (AMI)<br />

- for tidlig lukning PGE 1<br />

(alprostadil)<br />

- forsinket lukning NSAID<br />

- ASA inaktiverer COX I+II<br />

(TXA 2<br />

og PGI 2<br />

9 (dosis !!))<br />

Diætetisk påvirkning af arachidonsyre-metabolismen vha polyumættede<br />

fedtsyrer (ex. linolensyre) <br />

Nyrer<br />

PG betydning for autoregulation - obs behandling med NSAID<br />

TXA 2<br />

produceres ved inflammation (ex. glomerulonefrit)<br />

- reduceret nyrefunktion

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