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Inflammation - Institutleder til klinisk medicin

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Eicosanoider<br />

Derivater af polyumættede fedtsyrer (arachidonsyre)<br />

med 20 kulstofatomer-carbon (eicosa=20)<br />

- Prostaglandiner<br />

- Tromboxaner<br />

- Leukotriener<br />

- Lipoxiner<br />

- Epoxider (P450 monooxygenase derivater)<br />

- Isoprostaner (peroxidering vha frie radikaler)<br />

- PAF<br />

Fosfolipid<br />

Fosfolipase A 2<br />

PAF<br />

Lipoxiner<br />

Chemotaxin<br />

Epoxider<br />

Isoprostaner<br />

COX I og II<br />

Arachidonsyre<br />

5-LO<br />

Prostacyclin syntase<br />

PGI 2<br />

(prostacyclin)<br />

PGD 2<br />

TxA 2<br />

LTD 4<br />

LTE 4<br />

5-HPETE<br />

PGG 2<br />

, PGH 2<br />

LTA 4 LTB 4<br />

Isomeraser Tx syntase<br />

LTC 4<br />

PGE 2<br />

PGF<br />

(cysteinyl-LT)

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