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İntratimpanik Uygulamalar Popüler Bir Yöntem Üzerine Derleme

İntratimpanik Uygulamalar Popüler Bir Yöntem Üzerine Derleme

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YILMAZ Ý, AKKUZU B, ÖZLÜOÐLU LN.<br />

destrüktif olmayýp gentamisinin tersine<br />

baþlangýç tedavisi olarak önerilmektedirler.<br />

Gelecekte her iki uygulamanýn da dozlarýnda<br />

deðiþiklik olabileceði ve kombinasyonlarýnýn<br />

kullanýlabileceði sanýlmaktadýr.<br />

Bu literatür incelemesine göre; gentamisin<br />

uygulamalarýnýn daha eskiye dayanmasý sonucunda<br />

oluþmuþ tecrübenin protokollerin yerleþmesini<br />

saðladýðý; buna karþýn steroid (deksametazon)<br />

uygulamalarýnýn henüz deney aþamasýnda<br />

olduðu ve klinik çalýþmalarýn da yeter-<br />

1. Itoh A, Sakata E. Treatment of vestibular disorders. Acta<br />

Otolaryngol (Stockh) 1991; Suppl.481:617-23.<br />

2. Sennaroðlu L, Sennaroðlu G, Gursel B, et al.<br />

3.<br />

Intratympanic dexamethasone, intratympanic gentamicin,<br />

and endolymphatic sac surgery for intractable vertigo in<br />

Meniere’s disease. Otolaryngol Head Neck Surg 2001;<br />

125:537-43.<br />

Yamazaki T, Hayashi M, Komatsuzaki A. Intratympanic<br />

gentamicin therapy for Meniere’s disease placed by a<br />

tubal catheter with systematic isosorbide. Acta<br />

4.<br />

Otolaryngol (Stockh) 1991; Suppl. 481:613-16.<br />

Nedzelski JM, Schessel DA, Bryce GE, Pfleiderer AG.<br />

Chemical labyrinthectomy: Local application of gentamicin<br />

for the treatment of unilateral Meniere’s disease. Am<br />

J Otol 1992; 13(1):18-22.<br />

5. McFeely WJ, Singleton GT, Rodriguez FJ, et al.<br />

Intratympanic gentamicin treatment for Meniere’s disease.<br />

Otolaryngol Head Neck Surg 1998; 118.589-96.<br />

6. Blakley BW. Clinical forum: A review of intratympanic<br />

therapy. Am J Otol 1997; 18: 520-6.<br />

7. Chandrasekhar SS, Rubinstein RY, Kwartler JA et al.<br />

Dexamethasone pharmacokinetics in the inner ear:<br />

Comparison of route of administration and use of facilitating<br />

agents. Otolaryngol Head Neck Surg 2000;122:<br />

521-8.<br />

8. Juhn SK, Hamaguchi Y, Goycoolea M. Review of round<br />

window membrane permeability. Acta Otolaryngol<br />

(Stockh) 1988; Suppl.457:43-8.<br />

9. Abou-Halawa AS, Poe DS. Efficacy of increased gentamycin<br />

concentration for intratympanic injection therapy<br />

in Meniere's disease. Otology&Neurotology 2002; 23:<br />

494-503.<br />

10. Monsell EM, Cass SP, Rybak LP. Chemical labyrinthectomy:<br />

Methods and results. In: Brackmann DE (eds):<br />

Otologic Surgery, 1st ed. Philadelphia, W.B.Saunders Co,<br />

1994, 509-18.<br />

11. Hibi T, Suzuki T, Nakashima T. Perilymphatic concentration<br />

of gentamicin administered intratympanically in guinea<br />

pigs. Acta Otolaryngol 2001; 121:336-41.<br />

12. Beck C, Schmidt CL. 10 years of experience with intratympanically<br />

applied streptomycin (gentamicin) in the thera-<br />

154<br />

KAYNAKLAR<br />

siz olduðu kanýsýna varýlmýþtýr. Ýntratimpanik<br />

steroidlerin klinik kullanýmý konusunda yeni<br />

çalýþmalara gereksinim duyulmaktadýr.<br />

Yazýþma Adresi:<br />

Uz.Dr. Ýsmail YILMAZ<br />

Baþkent Üniversitesi Adana Seyhan Hastanesi<br />

Kulak Burun Boðaz Bölümü Baraj Yolu 1. Durak No:37<br />

01110 Seyhan / ADANA<br />

Tel : 0 322 458 68 68<br />

Faks : 0 322 453 79 79<br />

e-mail : iy38@yahoo.com<br />

py of morbus Meniere. Arch Otorhinolaryngol 1978;<br />

221:149-52.<br />

13. Balyan FR, Taibah A, De Donato G et al. Titration streptomycin<br />

therapy in Meniere’s disease: Long-term results.<br />

Otolaryngol Head Neck Surg 1998; 118:261-6.<br />

14. Blakley BW. Update on intratympanic gentamicin for<br />

Meniere’s disease. Laryngoscope 2000; 110:236-40.<br />

15. Schacht J. Biochemical basis of aminoglycoside ototoxicity.<br />

Otolaryngol Clin North Am 1993; 26(5):845-56.<br />

16. Roland JT, Cohen NL. Vestibular and auditory ototoxicity.<br />

In: Cummigs CW(ed). Otolaryngology Head and Neck<br />

Surgery, 3rd ed. St Louis, Mosby. 1998:3186-97.<br />

17. Bagger-Sjoback D. Effect of streptomycin and gentamicin<br />

on the iner ear. Ann NY Acad Sciences 1997;<br />

830(Pt3):120-9.<br />

18. Brummett RE, Haris RF, Lundgren JA. Detection of ototoxicity<br />

from drugs applied topically to the middle ear<br />

space. Laryngoscope 1976; 86(2):1177-87.<br />

19. Youssef TF, Poe DS. Intratympanic gentamicin injection<br />

for the treatment of Meniere’s disease. Am J Otol 1998;<br />

19:435-42.<br />

20. Hirsch BE, Kamerer DB. Intratympanic gentamicin for<br />

Meniere's disease. Am J Otol 1997; 18:44-51.<br />

21. Quaranta A, Scaringi A, Aloisi A et al. Intratympanic therapy<br />

for Meniere’s disease: Effect of administration of low<br />

concentration of gentamicin. Acta Otolaryngol 2001;<br />

121:387-92.<br />

22. Bauer PW, MacDonald CB, Cox CL. Intratympanic gentamicin<br />

therapy for vertigo in nonserviceable ears. Am J<br />

Otolaryngol 2001; 22:111-15.<br />

23. Yetiþer S, Kertmen M. Intratympanic gentamicin in<br />

Meniere's disease: the impact on tinnitus. Int J Audiol<br />

2002; 41:363-70.<br />

24. Driscoll CLW, Kasperbauer JL, Facer GW et al. Low-dose<br />

intratympanic gentamicin and the treatment of Meniere’s<br />

disease: preliminary results. Laryngoscope 1997; 107:83-<br />

9.<br />

25. Pfleiderer AG. The current role of lokal intratympanic gentamicin<br />

therapy in the management of unilateral<br />

Meniere’s disease. Clin Otolaryngol 1998; 23:34-41.<br />

OTOSKOP 2003;3:145-155

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