İntratimpanik Uygulamalar Popüler Bir Yöntem Üzerine Derleme
İntratimpanik Uygulamalar Popüler Bir Yöntem Üzerine Derleme
İntratimpanik Uygulamalar Popüler Bir Yöntem Üzerine Derleme
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YILMAZ Ý, AKKUZU B, ÖZLÜOÐLU LN.<br />
destrüktif olmayýp gentamisinin tersine<br />
baþlangýç tedavisi olarak önerilmektedirler.<br />
Gelecekte her iki uygulamanýn da dozlarýnda<br />
deðiþiklik olabileceði ve kombinasyonlarýnýn<br />
kullanýlabileceði sanýlmaktadýr.<br />
Bu literatür incelemesine göre; gentamisin<br />
uygulamalarýnýn daha eskiye dayanmasý sonucunda<br />
oluþmuþ tecrübenin protokollerin yerleþmesini<br />
saðladýðý; buna karþýn steroid (deksametazon)<br />
uygulamalarýnýn henüz deney aþamasýnda<br />
olduðu ve klinik çalýþmalarýn da yeter-<br />
1. Itoh A, Sakata E. Treatment of vestibular disorders. Acta<br />
Otolaryngol (Stockh) 1991; Suppl.481:617-23.<br />
2. Sennaroðlu L, Sennaroðlu G, Gursel B, et al.<br />
3.<br />
Intratympanic dexamethasone, intratympanic gentamicin,<br />
and endolymphatic sac surgery for intractable vertigo in<br />
Meniere’s disease. Otolaryngol Head Neck Surg 2001;<br />
125:537-43.<br />
Yamazaki T, Hayashi M, Komatsuzaki A. Intratympanic<br />
gentamicin therapy for Meniere’s disease placed by a<br />
tubal catheter with systematic isosorbide. Acta<br />
4.<br />
Otolaryngol (Stockh) 1991; Suppl. 481:613-16.<br />
Nedzelski JM, Schessel DA, Bryce GE, Pfleiderer AG.<br />
Chemical labyrinthectomy: Local application of gentamicin<br />
for the treatment of unilateral Meniere’s disease. Am<br />
J Otol 1992; 13(1):18-22.<br />
5. McFeely WJ, Singleton GT, Rodriguez FJ, et al.<br />
Intratympanic gentamicin treatment for Meniere’s disease.<br />
Otolaryngol Head Neck Surg 1998; 118.589-96.<br />
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therapy. Am J Otol 1997; 18: 520-6.<br />
7. Chandrasekhar SS, Rubinstein RY, Kwartler JA et al.<br />
Dexamethasone pharmacokinetics in the inner ear:<br />
Comparison of route of administration and use of facilitating<br />
agents. Otolaryngol Head Neck Surg 2000;122:<br />
521-8.<br />
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window membrane permeability. Acta Otolaryngol<br />
(Stockh) 1988; Suppl.457:43-8.<br />
9. Abou-Halawa AS, Poe DS. Efficacy of increased gentamycin<br />
concentration for intratympanic injection therapy<br />
in Meniere's disease. Otology&Neurotology 2002; 23:<br />
494-503.<br />
10. Monsell EM, Cass SP, Rybak LP. Chemical labyrinthectomy:<br />
Methods and results. In: Brackmann DE (eds):<br />
Otologic Surgery, 1st ed. Philadelphia, W.B.Saunders Co,<br />
1994, 509-18.<br />
11. Hibi T, Suzuki T, Nakashima T. Perilymphatic concentration<br />
of gentamicin administered intratympanically in guinea<br />
pigs. Acta Otolaryngol 2001; 121:336-41.<br />
12. Beck C, Schmidt CL. 10 years of experience with intratympanically<br />
applied streptomycin (gentamicin) in the thera-<br />
154<br />
KAYNAKLAR<br />
siz olduðu kanýsýna varýlmýþtýr. Ýntratimpanik<br />
steroidlerin klinik kullanýmý konusunda yeni<br />
çalýþmalara gereksinim duyulmaktadýr.<br />
Yazýþma Adresi:<br />
Uz.Dr. Ýsmail YILMAZ<br />
Baþkent Üniversitesi Adana Seyhan Hastanesi<br />
Kulak Burun Boðaz Bölümü Baraj Yolu 1. Durak No:37<br />
01110 Seyhan / ADANA<br />
Tel : 0 322 458 68 68<br />
Faks : 0 322 453 79 79<br />
e-mail : iy38@yahoo.com<br />
py of morbus Meniere. Arch Otorhinolaryngol 1978;<br />
221:149-52.<br />
13. Balyan FR, Taibah A, De Donato G et al. Titration streptomycin<br />
therapy in Meniere’s disease: Long-term results.<br />
Otolaryngol Head Neck Surg 1998; 118:261-6.<br />
14. Blakley BW. Update on intratympanic gentamicin for<br />
Meniere’s disease. Laryngoscope 2000; 110:236-40.<br />
15. Schacht J. Biochemical basis of aminoglycoside ototoxicity.<br />
Otolaryngol Clin North Am 1993; 26(5):845-56.<br />
16. Roland JT, Cohen NL. Vestibular and auditory ototoxicity.<br />
In: Cummigs CW(ed). Otolaryngology Head and Neck<br />
Surgery, 3rd ed. St Louis, Mosby. 1998:3186-97.<br />
17. Bagger-Sjoback D. Effect of streptomycin and gentamicin<br />
on the iner ear. Ann NY Acad Sciences 1997;<br />
830(Pt3):120-9.<br />
18. Brummett RE, Haris RF, Lundgren JA. Detection of ototoxicity<br />
from drugs applied topically to the middle ear<br />
space. Laryngoscope 1976; 86(2):1177-87.<br />
19. Youssef TF, Poe DS. Intratympanic gentamicin injection<br />
for the treatment of Meniere’s disease. Am J Otol 1998;<br />
19:435-42.<br />
20. Hirsch BE, Kamerer DB. Intratympanic gentamicin for<br />
Meniere's disease. Am J Otol 1997; 18:44-51.<br />
21. Quaranta A, Scaringi A, Aloisi A et al. Intratympanic therapy<br />
for Meniere’s disease: Effect of administration of low<br />
concentration of gentamicin. Acta Otolaryngol 2001;<br />
121:387-92.<br />
22. Bauer PW, MacDonald CB, Cox CL. Intratympanic gentamicin<br />
therapy for vertigo in nonserviceable ears. Am J<br />
Otolaryngol 2001; 22:111-15.<br />
23. Yetiþer S, Kertmen M. Intratympanic gentamicin in<br />
Meniere's disease: the impact on tinnitus. Int J Audiol<br />
2002; 41:363-70.<br />
24. Driscoll CLW, Kasperbauer JL, Facer GW et al. Low-dose<br />
intratympanic gentamicin and the treatment of Meniere’s<br />
disease: preliminary results. Laryngoscope 1997; 107:83-<br />
9.<br />
25. Pfleiderer AG. The current role of lokal intratympanic gentamicin<br />
therapy in the management of unilateral<br />
Meniere’s disease. Clin Otolaryngol 1998; 23:34-41.<br />
OTOSKOP 2003;3:145-155