inme olgularında protrombin gen mutasyonlarının rolü - Süleyman ...

647. SUMMARYStroke is one of the major causes of long-term disability which brings aboutpsychical and socioeconomic drawbacks for patients and their parents as well asmedical institutions. In effect, it should form a basis in combating with the stroke toascertain the risk factors and to eliminate these factors.Major diversities have been reported in the studies conducted for purposes ofstroke etiology. The scarcity of the samples in the studies, the variety of the methodsapplied and the ethnic groups have highly likely contributed to the diversity of theresults.The objective of this study has been to investigate the frequency of theprothrombin gene mutation on the progress of stroke. In our study, we have examined238 patients who have not been struck by stroke and 238 stroke patients.Following the study, occurrence rates of merely Factor V H1299R, Factor VLeiden and β Fibrinojen -455GA mutations have been found expressively high in thestroke patients in comparison to control group (p0.05). Some otherprothrombotical mutations such as Factor XIII V34L, MTHFR A1298C and MTHFRC677T have been detected in high ratios in both groups. However, no statisticallysignificant difference has been found between the patient group and control group.To sum up, in the light of these information we have drawn the conclusion thatthe stroke ethiopathogenesis is multifactorial and that prothrombotical gene mutationscan only form a risk factor when they appear together with other factors.Keywords: Stroke, Prothrombine gene mutations, Risk factors