Phenobarbital and its Sodium Salt - IARC Monographs on the ...

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Table 2 (contd) Country (reference) Subjects Exposure estimates Odds ratio (95% CI) Comments Childhood neuroblastoma USA (Kramer et al., 1987) Lung cancer Denmark (Olsen et al., 1993) Bladder cancer Denmark (Olsen et al., 1993) Primary liver cancer Denmark (Olsen et al., 1995) 104 patients 104 controls 104 patients 200 controls 18 patients 33 controls 26 patients 49 controls Mothers’ phenobarbital use Neurally active drugs <strong>Phenobarbital</strong> treatment Ever versus never 1–749 g ≥ 750 g <strong>Phenobarbital</strong> treatment Ever versus never 1–749 g ≥ 750 g <strong>Phenobarbital</strong> treatment Ever versus never 5–749 g ≥ 750 g [2.9%] [0.0%] 2.8 (1.3–6.0) 1.2 1.6 1.0 0.3 0.6 0.2 2.0 0.4 3.2 (0.7–2.2) (0.8–3.0) (0.5–1.8) (0.1–0.9) (0.1–2.7) (0.0–0.9) (0.5–7.2) (0.1–3.4) (0.7–14) Formal risk estimates were not provided. 90% CI 176 <strong>IARC</strong> MONOGRAPHS VOLUME 79
Table 2 (contd) Country (reference) Subjects Exposure estimates Odds ratio (95% CI) Comments Biliary-tract cancer Denmark (Olsen et al., 1995) Malignant lymphoma Denmark (Olsen et al., 1995) 13 patients 24 controls 21 patients 98 controls <strong>Phenobarbital</strong> treatment Ever versus never 5–749 g ≥ 750 g 1.5 1.3 1.6 (0.4-6.7) (0.3-7.0) (0.3-8.9) <strong>Phenobarbital</strong> treatment Ever versus never 1.5 (0.5–5.0) PHENOBARBITAL AND ITS SODIUM SALT 177
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In a review of exposure to anti-epi
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educed throughout life. Serum testo
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in CYP1A2 expression was also seen.
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Table 6 (contd) Test system Result
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Table 6 (contd) Test system Result
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Table 6 (contd) Test system Inhibit
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Table 6 (contd) Test system Inhibit
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these tumours was a CG → AT trans
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5. Summary of Data Reported <strong
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