Phenobarbital and its Sodium Salt - IARC Monographs on the ...

Table 4 (contd)
Strain (sex) Initiator, dose, route
<strong>and</strong> duration
CD (SD) BR
(M <strong>and</strong> F)
Fischer 344
(M)
Fischer 344
(M)
Fischer 344
(M)
Fischer
344/DuCrj
(M)
Fischer 344
(M)
NBHPA, 700 mg/kg bw ×
1 per week, sc, 5 weeks
Interval
between
initiator <strong>and</strong>
promoter
Dose, route <strong>and</strong> duration
of PB or NaPB
2 weeks PB, 500 mg/kg diet <strong>and</strong>/or
thyroxine, 15 weeks
NBHPA, 0.2% in water 1 week PB, 500 mg/kg diet,
50 weeks
IQ, 0.025, 0.05 or 0.1%
diet, 2 weeks
NDMA.OAc, 0.05
nmol/kg bw, ip
NBHPA, 2800 mg/kg bw,
sc
NDEA, 100 mg/kg bw, ip
× 1 (day 1) + MNU, 20
mg/kg bw, ip × 4 (day 2,
5, 8 <strong>and</strong> 11) + NBHPA,
0.1% in water, 2 weeks
(weeks 3–4)
Promoting effects on preneoplastic <strong>and</strong>/or
neoplastic thyroid lesions
Follicular-cell adenomas; M: NBHPA,
6/16; NBHPA + PB, 15/18; NBHPA
+ PB + thyroxine, 5/20; F: NBHPA
+ PB, 1/20
Reference
McClain et al.
(1988)
Follicular-cell adenomas Shirai et al.
(1988)
1 week PB, 0.05% diet Papillar adenomas <strong>and</strong> carcinomas;
IQ (0.1%), 5.3%; IQ + PB, 44–64%
2 weeks PB, 500 mg/L in
drinking-water,
50 or 78 weeks
1 week PB, 0.05% in water,
25 weeks
0 day NaPB, 500 mg/kg diet,
20 weeks
Follicular-cell tumours at 78 weeks;
NDMA.OAc, 1/15; NDMA.OAc
+ PB, 7/15
Multiple thyroid neoplasms; NBHPA,
3/30; NBHPA + PB, 14/30
Follicular-cell hyperplasia <strong>and</strong> adenoma:
initiated rats, 5/15 <strong>and</strong> 4/15; initiated rats
given NaPB, 14/15 <strong>and</strong> 12/15
Tsuda et al.
(1988)
Diwan et al.
(1989c)
Kanno et al.
(1990)
Shibata et al.
(1990)
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<strong>IARC</strong> MONOGRAPHS VOLUME 79