Phenobarbital and its Sodium Salt - IARC Monographs on the ...

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Table 5 (contd) Strain (sex) Initiator, dose, route <strong>and</strong> duration Male accessory gl<strong>and</strong>s Rat Wistar (M) MNU, 30 mg/kg bw, iv × 1 Gastrointestinal tract Rat Wistar (M) MNNG, 100 mg/L in water, 8 weeks Fischer 344 (M) NDMA.OAc, 0.05 nmol/kg bw, ip × 1 Interval between initiator <strong>and</strong> promoter Dose, route <strong>and</strong> duration of PB or NaPB 7 months PB, 500 mg/kg diet, 7 months 0 day PB, 0.05% diet, 32 weeks 2 weeks PB, 0.05% in water, 78 weeks Promoting effects on preneoplastic <strong>and</strong>/or neoplastic lesions PB promoted MNU-induced male accessory gl<strong>and</strong> carcinogenesis (prostate <strong>and</strong> seminal vesicle) PB had not effect on MNNGinduced gastro-duodenal tumours PB had no effect on NDMA.OAc-induced intestinal tumours Reference Pollard et al. (1995) Takahashi et al. (1984) Diwan et al. (1989c) 202 <strong>IARC</strong> MONOGRAPHS VOLUME 79
Table 5 (contd) DMBA, 7,12-dimethylbenz[a]anthracene ENU, N-ethyl-N-nitrosourea F, female FANFT, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide ip, intraperitoneally iv, intravenous;y M, male MNNG, N-methyl-N′-nitro-N-nitrosoguanidine MNU, N-methyl-N-nitrosourea NBHPA, N-nitrosobis(2-hydroxypropyl)amine NDBA, N-nitrosodibutylamine NDMA.OAc, N-nitrosodimethyl(acetoxymethyl)amine NR, not reported sc, subcutaneously PHENOBARBITAL AND ITS SODIUM SALT 203
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Page 3 and 4: (b) Spectroscopy data: Infrared [pr
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Table 6 (contd) Test system Inhibit
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Table 6 (contd) Test system Inhibit
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PHENOBARBITAL AND ITS SODIUM SALT 2
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these tumours was a CG → AT trans
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5. Summary of Data Reported <strong
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