methods for impurity profiling of heroin and cocaine - United Nations ...
methods for impurity profiling of heroin and cocaine - United Nations ...
methods for impurity profiling of heroin and cocaine - United Nations ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Methods <strong>for</strong> <strong>impurity</strong> <strong>pr<strong>of</strong>iling</strong> 45<br />
4. Additional <strong>methods</strong><br />
Method D7: GC-ECD method <strong>for</strong> unadulterated samples<br />
Source: J. M. Moore <strong>and</strong> D. A. Cooper, “The application <strong>of</strong> capillary gas chromatography-electron<br />
capture detection in the comparative analyses <strong>of</strong> illicit <strong>cocaine</strong> samples”,<br />
Journal <strong>of</strong> Forensic Sciences, vol. 38, No. 6 (1993), pp. 1286-1304.<br />
Rationale <strong>for</strong> use: This GC-ECD method provides <strong>for</strong> the detection <strong>and</strong> quantification<br />
<strong>of</strong> 6- <strong>and</strong> 7-exo <strong>and</strong> 6- <strong>and</strong> 7-endohydroxy<strong>cocaine</strong>s along with manufacturing byproducts<br />
<strong>of</strong> nor<strong>cocaine</strong> <strong>and</strong> benzoylnorecgonine methyl ester. The method is designed<br />
<strong>for</strong> unadulterated samples.<br />
Outcome: Aids in the evaluation <strong>of</strong> samples <strong>for</strong> case-to-case evidential purposes (linkage<br />
determinations). Provides additional in<strong>for</strong>mation required to confirm links between<br />
samples, that is, the method should be used in conjunction with a major component<br />
analysis.<br />
Method D8: GC/MS method <strong>for</strong> unadulterated samples<br />
Sources: J. F. Casale <strong>and</strong> J. M. Moore, “Lesser alkaloids <strong>of</strong> <strong>cocaine</strong>-bearing<br />
plants: III. 2-Carbomethoxy-3-oxo substituted tropane esters; detection <strong>and</strong> gaschromatographic-mass<br />
spectrometric characterization <strong>of</strong> new minor alkaloids found in<br />
South American Erythroxylum coca var. coca”, Journal <strong>of</strong> Chromatography A,<br />
vol. 756, Nos. 1-2 (1996), pp. 185-192; J. F. Casale, J. M. Moore <strong>and</strong> N. G. Odeneal,<br />
“Comparative determination <strong>of</strong> 2-carbomethoxy-3-alkyloxy- <strong>and</strong> heteroaroyloxysubstituted<br />
tropanes in illicit South American <strong>cocaine</strong> using capillary gas chromatography-single<br />
ion monitoring”, Journal <strong>of</strong> Forensic Sciences, vol. 43, No. 1 (1998),<br />
pp. 125-132.<br />
Rationale <strong>for</strong> use: This GC-MS method provides <strong>for</strong> the detection <strong>and</strong> quantification<br />
<strong>of</strong> 3-oxo-heteroaryl <strong>and</strong> 3-oxo-hydrocarbon substituted 2-carbomethoxytropanes.<br />
Detection is accomplished in the selected ion monitoring mode. The method is<br />
designed <strong>for</strong> unadulterated samples.<br />
Outcome: Aids in the evaluation <strong>of</strong> samples <strong>for</strong> case-to-case evidential purposes (linkage<br />
determinations). Provides additional in<strong>for</strong>mation required to confirm links between<br />
samples, that is, the method should be used in conjunction with a major component<br />
analysis.
Change language