methods for impurity profiling of heroin and cocaine - United Nations ...

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ANNEX III REFERENCE CHROMATOGRAMS AND PEAK IDENTIFICATION TABLES Figure I. Capillary gas chromatograms of illicit heroin samples (Top = uncut heroin sample; bottom = cut heroin sample) 63 Peaks: 1 = nicotinamide-TMS 2 = meconin 3 = caffeine 4 = glucose-TMS 5 = phenobarbital-TMS 6 = methaqualone 7 = acetylcodeine 8 = acetylthebaol 9 = morphine-TMS 10 = 6-O-acetylmorphine-TMS 11 = diacetylmorphine 12 = papaverine 13 = phenolphthalein-TMS 14 = narcotine S = n-tetracosane (internal standard) Note: TMS = trimethylsilyl derivative. Conditions: Fused silica capillary column 25 m x 0.32 mm i.d. coated with OV-1 crosslinked; carrier gas 0.7 bar hydrogen, split 20 ml/min; make-up gas 18 ml argon/min; oven temperature programme 150° C to 280° C at 9° C/min, then 0.5 min isothermal; and injector/detector (FID) temperatures 250° C/280° C. Source: Reprinted from Forensic Science International, vol. 44, No. 1, H. Neumann, “Comments on the routine profiling of illicit heroin samples”, pp. 85-87. Copyright 1990, with permission from Elsevier.
64 Methods for impurity profiling of heroin and cocaine Figure II. lectropherogram of a standard mixture of heroin, O 6 -monoacetylmorphine, O 3 -monoacetylmorphine, morphine, acetylcodeine, papaverine, codeine and noscapine Peaks: a = heroin (0.40 mg/ml) b = O 6 -monoacetylmorphine (0.09 mg/ml) c = O 3 -monoacetylmorphine (0.04 mg/ml) d = morphine (0.04 mg/ml) e = acetylcodeine (0.04 mg/ml) f = papaverine (0.04 mg/ml) g = codeine (0.04 mg/ml) h = noscapine (0.06 mg/ml) Conditions: A 64-cm (55.5 cm to detector window) x 50-µm i.d. fused silica capillary operating at 25° C and 30 kV with UV detection at 205 nm was used. Pressure injections of 500 mbar*s were used with a run buffer consisting of Celixir reagent B (pH 2.5) + 100 mM DM-ß-CD. For migration times, see table 1. Source: Reprinted from Journal of Chromatography A, vol. 1034, Nos. 1-2, I. S. Lurie and others, “Use of dynamically coated capillaries for the determination of heroin, basic impurities and adulterants with capillary electrophoresis”, pp. 227-235, Copyright 2004, with permission from Elsevier.
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METHODS FOR IMPURITY PROFILING OF H
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Note Operating and experimental con
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Contents page I. Introduction. . .
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I. INTRODUCTION A. Background In or
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Introduction 3 on the detection and
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II. ASPECTS OF DRUG CHARACTERIZATIO
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Aspects of drug characterization an
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Aspects of drug characterization an
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