methods for impurity profiling of heroin and cocaine - United Nations ...

More documents

Recommendations

Info

Annex III 69 Table 3. Identification of peaks in the capillary gas chromatogram in figure IV Peak Identification Molecular Base Relative Retention weight peak retention index time a 1 Meconine 194 165 0.152 1765 3 Unknown 204 0.364 2290 4 3,6-Dimethoxy-4,5-epoxyphenanthrene 252 237 0.383 2333 5 4-O-Thebaol 254 254 0.465 2522 7 4-O-Acetylthebaol 296 254 0.494 2591 9 4,6-Diacetoxy-3-methoxyphenanthrene 324 240 0.542 2708 10 Unknown 252 0.634 2944 11 6-O,N-Diacetylnorcodeine 369 87 0.646 2977 12 Unknown 254 0.653 2995 14 4-Acetoxy-3,6-dimethoxy-5- [2-(N-methylacetamido)]ethylphenanthrene 395 265 0.677 3064 15 3-O,6-O,N-Triacetylmorphine 397 87 0.690 3100 16 N-Acetylnorlaudanosine 385 234 0.707 3147 18 Unknown 151 0.808 3446 19 4-Acetoxy-3,6-dimethoxy-8- [2-(N-methylacetamido)]ethylphenanthrene 395 280 0.830 3515 20 N-Acetylnornarcotine 441 248 0.857 3601 21 (E)-N-Acetylanhydronornarceine 455 193 0.907 3757 22 (1R,9S)-1-Acetoxy-N-acetyl-1,9dihydro-anhydronornarceine 515 280 0.939 3848 23 (Z)-N-Acetylanhydronornarceine 455 193 0.950 3876 IS (C40) n-Tetracontane (internal standard) 562 1.000 4000 Source: Reprinted from Forensic Science International, vol. 114, No. 2, L. Strömberg and others, “Heroin impurity profiling: a harmonization study for retrospective comparisons”, pp. 67-88, Copyright 2000, with permission from Elsevier. a Based on n-tetracontane = 1.000.
70 Methods for impurity profiling of heroin and cocaine Figure V. Capillary gas chromatograms of a cocaine hydrochloride sample and a cocaine base sample a (A = cocaine hydrochloride sample; B = cocaine base sample) Source: J. F. Casale and R. W. Waggoner, Jr., “A chromatographic impurity signature profile analysis for cocaine using capillary gas chromatography”, Journal of Forensic Sciences, vol. 36, No. 5 (1991), pp. 1312-1330. Copyright ASTM International. Reprinted with permission. a For peak identification, see table 4.
Page 1 and 2:
METHODS FOR IMPURITY PROFILING OF H
Page 3 and 4:
Note Operating and experimental con
Page 6 and 7:
Contents page I. Introduction. . .
Page 8 and 9:
I. INTRODUCTION A. Background In or
Page 10 and 11:
Introduction 3 on the detection and
Page 12 and 13:
II. ASPECTS OF DRUG CHARACTERIZATIO
Page 14 and 15:
Aspects of drug characterization an
Page 16 and 17:
Page 18 and 19:
Page 20 and 21:
III. METHODS FOR IMPURITY PROFILING
Page 22 and 23:
Methods for impurity profiling 15 a
Page 24 and 25:
Methods for impurity profiling 17 M
Page 26 and 27: Methods for impurity profiling 19 R
Page 30 and 31: Methods for impurity profiling 23 I
Page 34 and 35: Methods for impurity profiling 27 p
Page 36 and 37: Methods for impurity profiling 29 M
Page 38 and 39: Methods for impurity profiling 31 S
Page 40 and 41: Methods for impurity profiling 33 I
Page 42 and 43: Methods for impurity profiling 35 C
Page 46 and 47: Methods for impurity profiling 39 T
Page 52 and 53: Methods for impurity profiling 45 4
Page 54 and 55: IV. DATA HANDLING, INTERPRETATION O
Page 56 and 57: Data handling, interpretation of re
Page 58 and 59: References 1. “Report of an exper
Page 60 and 61: References 53 31. H. Neumann and G.
Page 62: ANNEX I SUPPLEMENTARY INFORMATION (
Page 65 and 66: 58 Methods for impurity profiling o
Page 70 and 71: ANNEX III REFERENCE CHROMATOGRAMS A
Page 72 and 73: Annex III 65 Table 1. Relative migr
Page 74 and 75: Annex III 67 Table 2. Relative migr
Page 78 and 79: Annex III 71 Table 4: Retention tim
Page 80: Annex III 73 Figure VII. Expanded
Page 90 and 91: *0583802* Printed in Austria V.05-8
show all

methods for impurity profiling of heroin and cocaine - United Nations ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?