E. coli - ForteBio
E. coli - ForteBio
E. coli - ForteBio
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Why Aren’t Bound Bacteria Inducing More<br />
Signal?<br />
• Bacteria are massive compared to the<br />
antibodies on the surface on the tip<br />
– ~950 bacteria should be able to bind the tip under<br />
perfect conditions<br />
• Bacteria aren’t all that dense<br />
– Mostly water, which light can penetrate easily<br />
– E. <strong>coli</strong> are Gram-negative and have a thin cell well<br />
• Bacteria are odd shaped<br />
– Comparing a cube to a football<br />
– Leads to inefficient loading at the tip surface
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