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Bz N MeO2C Bn 1-Benzoyl-2-benzyl-5-benzylidene-4-vinyl-1,2,5,6-tetrahydropyridine-2-carboxylic acid methyl ester (111d). Prepared by following general procedure G, using: 73d (26 mg, 58 µmol), 111d [Rh(CO)2Cl]2 (1 mg, 3 µmol). Yield 111d (21 mg, 81%). 1 H NMR (300 MHz, CDCl3): δ 7.29-7.00 (m, 13 H), 6.82-6.79 (m, 2H), 6.61 (s, 1H), 6.43 (ddd, J = 17.3, 10.7, 0.8 Hz, 1H), 5.89 (s, 1H), 5.56 (dd, J = 17.3, 1.5 Hz, 1H), 5.33 (dd, J = 10.7, 1.5 Hz, 1H), 4.41 (d, J = 14.2 Hz, 1H), 4.10 (d, J = 13.6 Hz, 1H), 3.77 (s, 3H), 3.41 (d, J = 13.6 Hz, 1H), 2.68 (d, J = 14.2, 1.4 Hz, 1H); 13 C NMR (75 MHz, CDCl3): δ 172.1, 171.2, 139.8, 136.9, 136.1, 135.8, 134.5, 131.0, 130.5, 129.7, 128.8, 128.5, 128.4, 128.0, 127.5, 127.1, 127.0, 125.6, 118.5, 66.9, 53.2, 45.4, 40.3; IR (thin film): ν 2918, 1738, 1639, 1413, 1223 cm -1 ; MS m/z (%) 449 (10), 390 (15), 358 (50), 105 (100); EI-HRMS calcd for C30H27NO3 m/z [M] + 449.1991; found 449.2011. Bz MeO 2C TBSO 1-Benzoyl-2-(tert-butyldimethylsilyloxymethyl)-5-ethylidene-4-vinyl-1,2,5,6- N tetrahydropyridine-2-carboxylic acid methyl ester (111e). Prepared by following general procedure G, using: 73e (36 mg, 83 µmol), [Rh(CO)2Cl]2 (1.5 mg, 5 µmol). Yield 111e (32 mg, 89%). 1 H NMR (300 MHz, CDCl3): δ (7.47-7.40 (m, 5H), 6.38 (dd, J = 17.2, 10.7 Hz, 1H), 5.75 (q, J = 7.0 Hz, 1H), 5.57 (s, 1H), 5.44 (dd, J = 17.2, 1.5 Hz, 1H), 5.21 (dd, J = 10.7, 1.5 Hz, 1H), 4.70 (d, J = 10.2 Hz, 1H), 4.51 (d, J = 14.1 Hz, 1H), 4.19 (d, J = 10.2 Hz, 1H), 3.99 (d, J = 14.0 Hz, 188 111e Ph
1H), 3.69 (s, 3H), 1.58 (d, J = 7.1 Hz, 1H), 0.85 (s, 9H), 0.06 (s, 3H), 0.05 (s, 3H); 13 C NMR (75 MHz, CDCl3) δ 170.9, 170.8, 139.6, 136.2, 134.4, 129.9, 129.7, 128.5, 127.0, 122.6, 122.4, 117.5, 66.3, 65.4, 52.5, 45.4, 25.8, 18.1, 13.4, -5.4, -5.5; IR (thin film): ν 2954, 2929, 2037, 1740, 1644 cm -1 ; MS m/z (%) 441 (23), 411 (63), 384 (66), 296 (100); EI-HRMS calcd for C25H35NO4Si m/z [M] + 441.2335; found 441.2333. Cbz MeO 2C N 5-Ethylidene-2-methyl-4-vinyl-5,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (111f). Prepared by following general procedure G, using: 73f (0.515 g, 1.51 mmol), [Rh(CO)2Cl]2 (24 mg, 62 µmol). Yield 111f (420 mg, 81%). 1 H NMR (300 MHz, DMSO-d6, 323 K): δ 7.37-7.33 (m, 5H), 6.40 (dd, J = 17.2, 10.8 Hz 1H), 5.76 (q, J = 7.0 Hz, 1H), 5.50 (bs, 1H), 5.40 (dd, J = 17.2, 1.3 Hz 1H), 5.19 (dd, J = 10.8, 1.3 Hz, 1H), 5.15 (d, J = 12.4 Hz, 1H), 5.10 (d, J = 12.4 Hz, 1H), 4.58 (d, J = 14.6 Hz, 1H), 3.79 (d, J = 14.6 Hz, 1H), 3.49 (s, 3H), 1.76 (d, J = 7.0 Hz, 3H), 1.55 (s, 3H); 13 C NMR (75 MHz, DMSO-d6, 323K): δ 171.5, 154.1, 136.1, 135.3, 133.6, 128.9, 128.0, 127.5, 127.2, 123.9, 122.2, 117.0, 66.4, 61.6, 51.8, 12.7; IR (thin film): ν 2949, 1743, 1704, 1404, 1243, 1110 cm -1 ; MS m/z (%) 341 (26), 282 (26), 238 (15), 91 (100); EI-HRMS calcd for C20H23NO4 [M] + m/z 341.1621, found 341.1627. Cbz MeO 2C N 2-Methyl-5-methylene-4-vinyl-5,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (111g). Prepared by following general procedure G, using: 73g (37 mg, 110 111f 111g µmol), [Rh(CO)2Cl]2 (2 mg, 5 µmol). Yield 111g (31 mg, 84%). 189
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TRANSITION METAL-CATALYZED REACTION
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Transition Metal-Catalyzed Reaction
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List of Abbreviations Ac acetyl AcO
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Table of Contents 1.0 Introduction.
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Appendix A : X-ray crystal structur
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Table 4.8 Rh(I)-catalyzed cyclocarb
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List of Schemes Scheme 1.1 Three fo
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Scheme 3.24 Preparation of amide-te
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Scheme 4.16 Formation of bicyclo[5.
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1.0 Introduction 1.1 The Role of Di
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According to these guidelines, the
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Scheme 1.1 Three forms of diversity
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Another example from the Schreiber
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1.1.1 Transition Metal-Catalyzed Re
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37, , such reactions include transi
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the proximal olefin of allenyne 38
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2.0 Design and Synthesis of the Piv
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The allenic amino acid derivatives
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This protocol proved particularly u
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ZnCl2, which results in a Zn-chelat
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Scheme 2.7 Synthesis of trisubstitu
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THF), the yield was increased from
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the terminus of the alkyne led to d
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N-Alkylation of the glycine-derived
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circumvent this issue, variants suc
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BINAP as a chiral ligand to obtain
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stereochemistry of the exocyclic ol
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3.2 Rhodium(I)-Catalyzed Allenic Cy
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exocyclic olefin geometry is not re
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3.2.1 Preparation of Enol-ether Tri
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Scheme 3.15 Synthesis of cycloisome
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Scheme 3.17 Cycloisomerization of a
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Scheme 3.19 Tandem cycloadditions o
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Scheme 3.21 Intermolecular Diels-Al
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attractive, since additional functi
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increased yield of the triene (47%)
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as an isobutyl-amide 155b was prepa
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group) demonstrated that this cyclo
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in 1M HCl/dioxane (1 : 1) for 1h, t
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ppm (dd, J = 7.1, 4.6 Hz, 1H) assig
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http://ccc.chem.pitt.edu/). Using f
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Notably, exclusive cycloisomerizati
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intermediate in the reaction we sou
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epulsive dipole interactions (Schem
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Table 3.4 Diels-Alder reactions of
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allenic Alder-ene reaction, ene-all
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Figure 3.4 Examples of natural prod
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species onto the proximal double bo
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Scheme 3.49 Rh(I)-catalyzed ene rea
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y Magnus 144 and it involves the in
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usually is DMSO. Heating to 100 ºC
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that require high pressures of CO.
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In contrast to the Mo(CO)6-mediated
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Scheme 4.15 Rh(I)-catalyzed allenic
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4.2 Rhodium(I)-Catalyzed Cyclocarbo
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lack of double bond selectivity, si
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Table 4.2 Cyclocarbonylation reacti
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Notably, the allenic cyclocarbonyla
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Scheme 4.22 Cyclocarbonylation reac
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neat or in solution. This decomposi
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the newly synthesized fulvenes (e.g
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stereocenters and mixture of E/Z is
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proximal double bond to give α-alk
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the methyl ester and Ha are syn. Sc
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that the major diastereomer in the
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We were motivated to first examine
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Scheme 4.42 Synthesis of pyrrole 29
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periodic acid (H5IO6). 209 These hi
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eaction failed to go to completion,
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4.5.2 Synthesis of a Library of Tri
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diketones 312{1-3,1-2} in yields ra
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Figure 4.2 Distribution for physico
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tricyclic pyrrole 314{3,2,26} (Figu
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4.6 Synthesis of α-Alkylidene Cycl
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anched and linear carboxylic acid i
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eactivity of the species prepared i
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considerably lower than the ratio o
Page 155 and 156: diastereomer. Next, allenyne 328 wa
Page 157 and 158: Conclusions In summary, we have dem
Page 159 and 160: Experimental Section General Method
Page 161 and 162: General procedure A for esterificat
Page 163 and 164: F Bz N H 56f 2-Benzoylamino-3-(4-fl
Page 165 and 166: MeO2C Bz N H 58c 2-Benzoylamino-2-m
Page 167 and 168: MeO MeO2C Bz N H 58e 2-Benzoylamino
Page 169 and 170: mL) and MeOH (10 mL) instead of sat
Page 171 and 172: hexanes-EtOAc, 19 : 1 to 4 : 1, v/v
Page 173 and 174: which was immediately used in the C
Page 175 and 176: Boc TMS N H Bn 64f tert-Butyl-1-((4
Page 177 and 178: MeI (38 µL, 0.62 mmol). Yield 65a
Page 179 and 180: with brine and concentrated under v
Page 181 and 182: H MeO 2C • H Bn NHBoc tert-Butyl-
Page 183 and 184: TMS MeO 2C • 70 H H NHBoc 2-tert-
Page 185 and 186: 185 (10), 141 (21), 57 (100); EI-HR
Page 187 and 188: dispersion in mineral oil, 1.0 mmol
Page 189 and 190: EI-HRMS calcd for C30H26NO3 m/z [M-
Page 191 and 192: CbzN MeO 2C Me 73h 2-[Benzyloxycarb
Page 193 and 194: CbzN MeO 2C Me 2-(Benzyloxycarbonyl
Page 195 and 196: dispersion in mineral oil, 3.85 mmo
Page 197 and 198: completion of the addition, the rea
Page 199 and 200: BzN MeO 2C S 74h 2-(Benzoylprop-2-y
Page 201 and 202: BzN MeO 2C Bn 75b 2-(Allylbenzoylam
Page 203 and 204: BzN MeO 2C TBSO 75e 2-(Benzoylbut-2
Page 205: Hz, 1H), 5.85 (s, 1H), 5.52 (dd, J
Page 209 and 210: µmol), [Rh(CO)2Cl]2 (1 mg, 3 µmol
Page 211 and 212: 1.25 (m, 6H), 0.88 (t, J = 6.9 Hz,
Page 213 and 214: 6.72 (d, J = 7.6 Hz, 0.5H), 6.68 (d
Page 215 and 216: BzN MeO2C Bn 122a Methyl-2-(N-(but-
Page 217 and 218: Bz N MeO2C Bn 1-Benzoyl-2-benzyl-4-
Page 219 and 220: 13.9, 5.3 Hz, 1H), 2.51-2.47 (m, 1H
Page 221 and 222: 15 min the solvent was removed unde
Page 223 and 224: Benzoyl chloride (0.169 mL, 1.46 mm
Page 225 and 226: mg, 0.11 mmol), [Rh(CO)2Cl]2 (4 mg,
Page 227 and 228: mL). kk The aqueous layer was extra
Page 229 and 230: ºC. After quenching the reaction b
Page 231 and 232: 129.8, 129.0, 128.7, 128.4, 126.2,
Page 233 and 234: MeO 2C O O O N H N R 1 O N Ph [10c-
Page 235 and 236: The crude residue was purified by f
Page 237 and 238: 14.4 Hz, 1H), 3.49-3.39 (m, 2H), 3.
Page 239 and 240: 1H), 5.49 (dd, J = 17.3, 1.8 Hz, 1H
Page 241 and 242: was stirred at rt for 1 h when it w
Page 243 and 244: BzN HOOC 2-(N-(but-2-ynyl)benzamido
Page 245 and 246: °C and DIBAL-H (0.440 mL of a 1.0M
Page 247 and 248: 129 (62), 91 (100); EI-HRMS calcula
Page 249 and 250: (d, J = 18.0 Hz, 1H), 4.14 (d, J =
Page 251 and 252: 4.98 (dt, J = 7.7, 5.1 Hz, 1H), 4.1
Page 253 and 254: N Bz MeO2C OTBS 214 1-Benzoyl-2-(te
Page 255 and 256: 270a (major diastereomer-eluting fi
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CDCl3): δ 7.42-7.17 (m, 13H), 7.04
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18.6 Hz, 1H), 4.34 (d, J = 18.0 Hz,
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Bz N MeO2C 2-Benzoyl-3,7-dimethyl-6
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v/v) afforded a mixture of compound
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(435 mg, 1.21 mmol), DMSO (429 µL,
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4.02 (s, 1H), 3.88 (s, 3H), 1.82 (s
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(207 mg, 96%) consisting of 287e (7
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procedure O, using: 74f (110 mg, 0.
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Bz N O H CO2Me BocN 287i 3-(2-Benzo
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4.17 (d, J = 15.0 Hz, 1H), 4.10 (d,
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137.1, 136.9, 130.4, 129.8, 128.5,
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H BzN MeO2C Bn H N C3H7 298b CO 2Me
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NMR (75 MHz, CDCl3): δ 172.3, 169.
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following the general procedure Q,
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H BzN MeO2C Bn H 5-Benzoyl-1,4-dibe
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119.9, 114.1, 109.9, 108.6, 73.0, 5
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4.11 (m, 1H), 4.07-3.98 (m, 1H), 3.
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126.8, 126.2, 109.0, 72.9, 58.7, 56
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NMR (75 MHz, CDCl3): δ 172.2, 169.
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3.0 Hz, 1H), 5.82-5.80 (m, 1H), 5.2
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87%). The diastereomeric ratio (288
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APPENDIX A: X-ray crystal structure
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APPENDIX B: X-ray crystal structure
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APPENDIX C: X-ray crystal structure
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APPENDIX D: X-ray crystal structure
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APPENDIX E: X-ray crystal structure
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APPENDIX F: QikProp property predic
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1 H and 13 C NMRs of 74b 293
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1 H and 13 C NMRs of 111a 295
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Page 317 and 318:
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1 H and 13 C NMRs of 270h 303
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Page 325 and 326:
1 H and 13 C NMRs of 307 307
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1 H and 13 C NMRs of 308n 309
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10. (a) Burke, M. D.; Schreiber, S.
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Hu, Y. J. Comb. Chem. 2006, 8, 286.
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49. For reviews on reactions of all
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69. (a) Trost, B. M.; Lautens, M.;
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containing cross-conjugated trienes
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Vaillancourt, J.; Rasper, D. M.; Ta
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130. Oppolzer, W.; Snieckus, V. Ang
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149. (a) Hicks, F. A.; Buchwald, S.
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Maiese, W. M. J. Antibiot. 2000, 53
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192. The mechanism of decomposition
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Boger, D. L.; Boyce, C. W.; Labroli
Page 351:
Generated Inhibitors of Human Mitog
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