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3.3.1 Intermolecular Diels-Alder Approach – First Generation Triene ......... 46
3.3.2 Intermolecular Diels-Alder Approach-Second Generation Triene........ 50
3.3.3 Intra-/Intermolecular Diels-Alder Approach for the Synthesis of
Complex Polycyclic Scaffolds.................................................................... 63
3.4 Rhodium(I)-Catalyzed Cycloisomerization of Ene-Allenes ............................ 72
4.0 Synthesis and Use of Amino-Acid Derived Cyclopentenones .................................. 80
4.1 Transition Metal Catalyzed Cyclocarbonylation – Pauson-Khand Reaction 80
4.1.1 Mo(CO)6-Mediated Cyclocarbonylation Reaction................................... 82
4.1.2 Late Transition Metal-Catalyzed Cyclocarbonylation Reaction............ 83
4.1.3 Allenic Cyclocarbonylation Reaction........................................................ 85
4.2 Rhodium(I)-Catalyzed Cyclocarbonylation of Amino-Ester Tethered
Allenynes for Preparation of 4-Alkylidene Cyclopentenones ......................... 91
4.3 Diversification of 4-Alkylidene Cyclopentenones ............................................ 99
4.4 Mo(CO)6-Mediated Cyclocarbonylation Reaction for Preparation of α-
Alkylidene Cyclopentenones ............................................................................ 104
4.5 Diversification of α-Alkylidene Cyclopentenones.......................................... 112
4.5.1 Studies Towards the Synthesis of Tricyclic Pyrroles............................. 112
4.5.2 Synthesis of a Library of Tricyclic Pyrroles........................................... 121
4.5.3 Biological Evaluation of Tricyclic Pyrroles ............................................ 126
4.6 Synthesis of α-Alkylidene Cyclopentenones via a Rhodium(I)-Catalyzed
Allenic Cyclocarbonylation Reaction.............................................................. 129
Conclusions................................................................................................................................ 139
Experimental Section................................................................................................................ 141
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