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MIT—Its Unique History, Culture, and Entrepreneurial Ecosystem<br />

companies had been documented by early 2008 as<br />

located within this complex, compared with fifty-five<br />

just three years prior. Thirteen of the Kendall Square<br />

life sciences companies accounted for two-thirds of<br />

the $1.8 billion Massachusetts companies spent on<br />

R&D in 2000. By the year 2001, twenty-one of the<br />

Kendall Square companies either were founded by<br />

MIT alumni or faculty, or had MIT-licensed<br />

technology; their revenues were $2.5 billion.<br />

Since 2001, the biotech numbers have continued<br />

to grow substantially. In ongoing research on the MITrelated<br />

life sciences complex in Cambridge, Professor<br />

Fiona Murray of MIT Sloan now finds that sixty-six of<br />

the 493 MIT “life scientists” (including those at the<br />

affiliated Broad and Whitehead Institutes) have<br />

founded or served on the boards of directors of at<br />

least one venture-funded company, totaling 134<br />

companies in all. Eighteen of these faculty or staff<br />

have founded or been board members of at least<br />

three companies each, with one MIT faculty member<br />

having twenty such relationships. Fifty additional MIT<br />

“life science” people serve as science advisory board<br />

members of an additional 108 companies, bringing a<br />

total of at least 242 life-science companies into strong<br />

ties with the MIT community. These ties are both<br />

cause and result of the interconnections between MIT<br />

and the entrepreneurial and industrial community. A<br />

large fraction of these life sciences faculty, post-docs,<br />

and staff do not have MIT degrees, and therefore are<br />

not counted among the MIT alumni entrepreneurship<br />

firms discussed in the earlier part of this <strong>report</strong>.<br />

Therefore, the economic and technological <strong>impact</strong> of<br />

these companies, by and large, supplement the data<br />

presented in the beginning of this <strong>report</strong>.<br />

Another sign of linkage of this cluster to MIT is<br />

the record of biotech/biomedical winners and runnersup<br />

in the MIT $50K Competition, the student-run<br />

business plan competition that will be discussed in<br />

greater depth later in this <strong>report</strong>. Data compiled by<br />

the MIT Entrepreneurship Center, listed in Table 9,<br />

shows fourteen bio-related companies in the last<br />

decade, several of which became real companies<br />

following their MIT $50K successes.<br />

Table 9<br />

Recent Biotech/Biomed MIT $50K Leaders<br />

Company Year Outcome<br />

SteriCoat 2006 Winner<br />

Balico 2005 Winner<br />

Active Joint Brace 2004 Winner<br />

SmartCells 2003 Winner<br />

Ancora Pharmaceuticals 2002 Finalist<br />

Crosslink Medical 2002 Finalist<br />

Angstrom Medical 2001 Winner<br />

Iptyx 2001 Finalist<br />

SiteSpecific Pharma 2001 Finalist<br />

SmartCure 2001 Finalist<br />

EyeGen 2000 Winner<br />

MolecularWare 1999 Winner<br />

Virtmed 1998 Finalist<br />

Actuality Systems 1997 Winner<br />

A second cluster has formed rapidly in the<br />

energy field. Over the past five decades, 3 percent<br />

of MIT entrepreneurs classified their firms as being in<br />

the energy sector. We now estimate that MIT alumni<br />

are creating thirty to thirty-five new energy-focused<br />

firms every year. Several hundred companies are in<br />

the New England energy cluster, with 263 in<br />

Massachusetts alone by early 2008. In Figure 16,<br />

we show the Boston metropolitan portion, containing<br />

twenty-two energy companies in Cambridge and<br />

twenty-five more in Boston. The broad geographic<br />

distribution of the energy firms, relative to the<br />

biotech companies shown in Figure 15, reflect the<br />

large number of source organizations of the energy<br />

companies, their wide diversity of technological<br />

bases, and their need for somewhat greater physical<br />

space than is readily available in central Cambridge.<br />

A high percentage of the new energy firms are<br />

MIT-related in terms of their founders and/or<br />

technology sources.<br />

ENTREPRENEURIAL IMPACT: THE ROLE OF MIT 37

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