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on Patent Policy was formed to address issues of<br />

ownership of inventions and discoveries stemming<br />

from research done at the Institute. In 1945, the<br />

Patent, Copyright and Licensing Office was<br />

established as part of the MIT Division of Sponsored<br />

Research, one of the earliest university efforts of its<br />

type in America. It became a separate entity and was<br />

renamed the Technology Licensing Office in 1985. As<br />

its formal function had been to facilitate patent<br />

applications, and to execute copyright and patent<br />

licenses with industry, government agencies, and<br />

other research institutions, the Patents office had<br />

been dominated by lawyers. With the 1985 entry of<br />

John Preston as director and Lita Nelsen ’66 as<br />

associate director, the lawyers were ousted and the<br />

TLO dramatically reoriented toward playing a far<br />

more active role in technology transfer. In that initial<br />

TLO year, the office put together eight to ten<br />

agreements with industry and registered<br />

approximately 120 invention disclosures. The latest<br />

figures average eighty to 100 agreements and about<br />

500 disclosures per year, now under Nelsen’s<br />

directorship for many years. The current TLO Web site<br />

describes its mission as “to benefit the public by<br />

moving results of MIT research into societal use via<br />

technology licensing, through a process that is<br />

consistent with academic principles, demonstrates a<br />

concern for the welfare of students and faculty, and<br />

conforms to the highest ethical standards.” It assists<br />

MIT inventors in protecting their technology and in<br />

An Evolving MIT Internal Entrepreneurial Ecosystem<br />

Table 15<br />

MIT Factors Important to Venture Founding (from li<strong>mit</strong>ed sample only)<br />

Graduation Decade 1950s 1960s 1970s 1980s 1990s<br />

(N=73) (N=111) (N=147) (N=144) (N=145)<br />

Students 26% 24% 38% 50% 66%<br />

Faculty 48% 42% 37% 28% 37%<br />

Research 32% 32% 30% 26% 33%<br />

*Respondents could check all relevant categories<br />

Proportion Rating University Factors as Important in Venture Founding* (percentage)<br />

licensing that technology to existing companies<br />

and startups.<br />

The TLO’s licensees fall into three categories—<br />

well-established (large) companies, small (often local)<br />

companies, and startups. Although the TLO’s licenses,<br />

in numbers, divide roughly evenly into the three<br />

categories, the majority of the exclusive licenses—the<br />

ones that fulfill TLO’s mission to encourage the<br />

development of truly innovative technologies<br />

requiring significant investment—go to startup<br />

companies.<br />

The primary reason for the TLO’s strategic<br />

dependence on startup companies has been the<br />

reluctance of large companies to invest in “universitystage”<br />

technologies, because the risk and cost of<br />

development is high and the time to market is long.<br />

In many fields (e.g., pharmaceuticals) the large<br />

companies have become dependent on startups to<br />

bring university-stage technology into proven product<br />

concepts, after which the large companies license the<br />

product from the startup or acquire the young<br />

company. But the TLO’s effectiveness in this strategy<br />

depends on venture investors’ willingness to invest in<br />

early-stage technology, somewhat scarce in recent<br />

years following the burst of the “dot-com” bubble<br />

and very scarce in the current severe economic<br />

downturn. The TLO strives to maintain a “level<br />

playing field” among many venture capital firms to<br />

attract them toward MIT startup opportunities by<br />

communicating fairness and openness. Fortunately,<br />

ENTREPRENEURIAL IMPACT: THE ROLE OF MIT 57

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