ABSTRACTS OF THE 21st ANNUAL MEETING OF THE ITALIAN ...

Abstracts of the 21st Annual Meeting of the Italian Society of Uro-Oncology (SIUrO), 22-24 June, 2011, Naples, Italy
Figure 1 (Abstract 257). Figure 2 (Abstract 257).
258
THE IMPACT OF THE EXTENT OF LYMPH-NODE
DISSECTION DURING RADICAL
CYSTECTOMY FOR BLADDER CANCER
ON CANCER-SPECIFIC SURVIVAL
Riccardo Schiavina, Alessandro Baccos, Hussam Dababhne,
Ziv Zukerman, Cosimo Bizzarri, Daniele Romagnoli,
Alessandro Bertaccini, Fabio Manferrari,
Eugenio Brunocilla, Marco Garofalo
and Giuseppe Martorana
Department of Urology, S. Orsola-Malpighi, University of
Bologna, Italy
Background: We evaluated the associations between the
number of lymph nodes retrieved during radical cystectomy
(RC) for bladder cancer (BC) and the cancer-specific survival
(CSS). Patients and Methods: We evaluated 229 consecutive
patients who had undergone RC for BC between November
1995 and October 2009 with complete follow-up data.
Table I (Abstract 255).
Exclusion criteria were: (i) neoadjuvant or adjuvant therapy,
(ii) palliative RC, (iii) pNx, and (iv) incomplete clinical and
pathological data. A total of 167 patients were evaluated,
divided into two LN groups according to the number of LNs
retrieved: group 1 (n=56, 33%) had 1 to 12 LNs removed,
while group 2 (n=111, 67%) had ≥13 LNs removed. The
primary endpoint was the evaluation of CSS. Results: The
mean follow-up was 52.6 (range: 1-172) months. Overall, the
CSS rate was 67.1% and 57.7% at five and ten years,
respectively. Cancer-specific death was observed for 51
(30.5%) patients. The mean number of LNs removed was 16.5
(range: 1-43); in pN+ patients, the mean number of positive
LNs was 5.6 (range: 1-19). Figure 1 shows the Kaplan–Meier
curves for CSS for the two groups of patients, divided
according to the number of LNs removed. Table I shows the
univariate and multivariate Cox analysis for clinical and
pathological characteristics correlated with CSS. Patients with
lower pathological stage, negative LN status, conventional
transitional cell carcinoma (TCC) and large number of LNs
retrieved had better CSS. Conclusion: In our study, patients
Univariate analysis Multivariate analysis
HR (95% CI) p-Value HR (95% CI) p-Value
Age (years) 1.018 (0.982-1.056) 0.326 - -
Gender (female vs. male) 1.940 (0.827-4.549) 0.128 - -
Pathological stage 1.791 (1.410-2.276)