ABSTRACTS OF THE 21st ANNUAL MEETING OF THE ITALIAN ...
ABSTRACTS OF THE 21st ANNUAL MEETING OF THE ITALIAN ...
ABSTRACTS OF THE 21st ANNUAL MEETING OF THE ITALIAN ...
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androgen receptor (AR). Despite anorchid serum androgen<br />
levels, nearly all patients develop castration-resistant disease.<br />
We hypothesized, on the basis of previous experience (1), that<br />
ongoing steroidogenesis within prostate tumors and the<br />
maintenance of intratumoral androgens may contribute to<br />
castration-resistant growth. Recently, Montgomery et al. (2)<br />
demonstrated that median testosterone levels within metastatic<br />
tumors from castrated men are approximately three-fold higher<br />
than the levels within primary prostate tumors from untreated<br />
eugonadal men. The study further showed statistically<br />
significant (p50%<br />
(median 87.1%, range 50.2% to 94.4%). PSA normalization (
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