ABSTRACTS OF THE 21st ANNUAL MEETING OF THE ITALIAN ...

Abstracts of the 21st Annual Meeting of the Italian Society of Uro-Oncology (SIUrO), 22-24 June, 2011, Naples, Italy
were comparable to those obtained in frozen tissues. Based
on miR-501 expression, renal carcinomas were divided into
four groups: (i) low expression, 5-fold. Overall, miR-501 expression was
down-regulated (group 1) in 12 patients (3 ccRCC, 7 pRCC,
1 chRCC and 1 oncocytoma); was normal in 10 patients (7
ccRCC, 2 pRCC and 1 lyposarcoma); weakly over-expressed
in 7 patients (4 ccRCC, 1 pRCC, 1 oncocytoma and 1
chRCC); strongly over-expressed in 9 ccRCC patients. No
correlation between miR-501 expression and tumor grading
was observed. Conclusion: Our results demonstrate that miR-
501 was mainly overexpressed in ccRCC, while it was mainly
unchanged or down-regulated in chRCC and pRCC. The
overexpression of miR-501 in ccRCC, therefore, may
contribute to features of this type of cancer and may play a
role in therapeutic response, metastasis development and
survival.
1 Di Leva G and Croce CM: Roles of small RNAs in tumor
formation. Trends Mol Med 16(6): 257-267, 2010.
2 Brannon AR and Rathmell WK: Renal cell carcinoma:
Where will the state-of-the-art lead us? Curr Oncol Rep
12(3): 193-201, 2010.
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RADICAL PROSTATECTOMY AND EXTENSIVE
PELVIC LYMPH NODE DISSECTION FOR
CLINICAL T3 PROSTATE CANCER:
SINGLE-CENTER LONG-TERM RESULTS
Maurizio Brausi, Giuseppe De Luca, Giorgio Verrini, Mirko
Gavioli, Giancarlo Peracchia, Gianluca Simonini, Massimo
Viola and Alberto Romano
UO Urologia AUSL di Modena, Modena, Italy
The objectives of this study were to evaluate the long-term
oncological results of all cT3 Prostate cancer (PCa) patients
who presented at our center from 2000 to 2005. Over- and
under-staging, together with overall survival (OS), diseasespecific
survival (DSS) and the morbidity of surgery were
evaluated. Patients and Methods: From the total of 1,195
radical prostatectomies (RPs) performed, 105 (8.8%) were
staged as cT3, 31 of which were excluded from the study
due to short follow-up, leaving 74 cT3 patients in the study.
The mean age was 68.1 (range 51-76) years and the mean
pre-operative PSA level was 24.5 (range 4-130) ng/ml. All
the patients were M0 (negative bone scan and computed
tomography). Bilateral extensive pelvic lymph node
dissection (EPLND) was performed in all patients. The
number of nodes removed varied from 20 to 45 (mean 32.5).
The retrograde extraponeurotic approach with removal of
Denonviller fascia was used. Nerve-sparing surgery was
never attempted. Additional surgical margins (bladder neck,
lateral, base and urethra) were taken for complete staging.
Results: Pathological staging was: pT2=15/74 patients
(20.3%): PT2a=6/15 (40%), pT2b=8/15(53.3%),
pT2c=1/15(6.7%). pT3=50/74 (67.5%): pT3a= 19/50 (38%),
pT3b= 31/50 (62%). PT4=9/74 (12.2%). A total of 29/74
patients had positive nodes (39.2%) and were all pT3 and
pT4: pT3a=15.7%, pT3b=74.3%, pT4=66.6%.They all
received immediate hormone therapy (HT). Overall, 45/74
cT3 pts. were N0 (60.8%). Grading: Gleason score