EAU 2013 - Programme Book - YouMed

Sunday, 17 March - EAU Programme
Thematic Session 4
11.00 - 12.00 Non-muscle invasive bladder cancer
Silver Hall - Level N2
Chair: J.W.F. Catto, Sheffield (GB)
11.00 - 11.15 State-of-the-art lecture Molecular sub-classification of bladder cancer
M. Sanchez-Carbayo, Madrid (ES)
Aims and objectives
As early events in bladder carcinogenesis, methylation and other epigenetic alterations would provide
diagnostic power complementing previously described genetic factors. As related to different steps in
tumor progression, they could also provide clinical utility for tumour sub-classification. Our group has
been working over the past years on characterising whether hypermethylation of profiles, focused panels
of tumor suppressor genes and individual candidates could classify bladder cancer subgroups according not
only to pathologic or clinical criteria but also to patient outcome. Part of our studies is aiming to evaluate
the clinical utility of CpG hypermethylation for the molecular classification of bladder tumours based on
their aggressiveness and clinical behaviour: from comprehensive CpG array methylation profiling, to several
multiplexed panels of TSGs, and finally characterising specific individual methylated candidates. In this
talk, the major results of these three strategies for bladder cancer sub-classification will be summarised:
using CpG arrays, methylation specific multiplex ligation-dependent probe amplification (MS-MLPA), and
methylation specific polymerase chain reactions (MS-PCR) analyses.
11.15 - 11.30 State-of-the-art lecture Photodynamic diagnosis: Fact or fiction?
M. Burger, Würzburg (DE)
Aims and objectives
The aims of this presentation is a comprehensive depiction of currently available data on the use of
photodynamic diagnosis in bladder cancer and a critical debate and evaluation of the evidence. The
first objective is the depiction of the potential impact of any method improving cystoscopic detection of
bladder cancer. The second objective is the description, the mode of action and debate of the feasibility
of photodynamic diagnosis. The third objective is an overview of currently available data on potential
improvements of detection and recurrence rates compared to standard white light cystoscopy. The fourth
objective is the debate of potential overall benefit for patients. The fifth objective is to pinpoint questions
unanswered to date and the sixth objective is the critical evaluation of what we know so far and a debate on
potential benefits and uncertainties.
11.30 - 11.45 State-of-the-art lecture New advances in perioperative instillation therapy in NMIBC
J.A. Witjes, Nijmegen (NL)
Aims and objectives
The initial resection of bladder tumors is a very important diagnostic and therapeutic tool. Therefore, optimal
initial treatment, including pre-, per-, or postoperative intravesical instillations or other means of help, is an
absolute must in bladder cancer treatment
EAU Milan 2013
165
Sunday