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Hypoplasia-Hyperplasia

Hypoplasia-Hyperplasia

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ע"<br />

שת/<br />

תבט/<br />

ד"<br />

י•<br />

40•<br />

Sequence<br />

Malformation sequence:<br />

Pierre-Robin, Klippel-Feil<br />

Deformation Sequence:<br />

Potter, Digeorge, Amniotic Band,<br />

Disruption sequence:<br />

TORCHES, Alcohol Fetal Synd, Thalidomide<br />

Vitamin A derivatives<br />

Pierre Robin Sequence<br />

Malformation sequence - the primary<br />

defect triggers a chain of secondary and<br />

tertiary events, resulting in what<br />

appears to be multiple anomalies.<br />

The later the defect is induced , the<br />

simpler is the malformation.<br />

Intrauterine<br />

mandibular<br />

hypoplasia<br />

Failure of<br />

tongue<br />

descent<br />

Robin sequence<br />

Cleft<br />

palate

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