Rudolph MG

Annu. Rev. Immunol. 2006.24:419-466. Downloaded from arjournals.annualreviews.org
by CAMBRIDGE UNIVERSITY on 04/04/10. For personal use only.
Table 4 Interactions of the peptide component of the pMHC with the TCR
# Total
contacts
# peptide
residues Peptide residue (P) and # contacts per residue
TCR/MHC/peptide
Peptide side-chain contacts with TCR
Human/mouse class I P1 P2 P3 P4 P5 P6 P7 P8
KB5-C20/H-2K b /pKB1 (1kj2) 8 1 0 0 7 0 1 5 0 14
2C/H-2K b /dEV8 (2ckb) 8 0 0 0 19 0 4 2 0 25
BM3.3/H-2K b /pBM1 (1fo0) 8 0 0 0 1 0 24 6 0 31
2C-H-2K b -SIYR (1g6r) 8 0 0 0 15 0 22 0 0 37
434 Rudolph· Stanfield· Wilson
2C-H-2K bm3 -dEV8 (1mwa) 8 0 0 0 16 0 24 1 0 41
BM3.3-H-2K-VSV8 (1nam) 8 0 0 0 22 0 7 0 0 29
P1 P2 P3 P4 P5 P6 P7 P8 P9
A6/HLA-A2/Tax (1ao7) 9 1 0 0 0 16 1 5 11 0 34
B7/HLA-A2/Tax (1bd2) 9 4 0 0 0 29 0 4 10 0 47
AHIII12.2/HLA-A2.1/p1049 (1lp9) 9 0 0 4 0 13 12 2 6 0 37
JM22/HLA-A2/MP58–66 (1oga) 9 0 0 0 0 5 3 2 6 0 16
LC13/HLA-B8/EBV (1mi5) 9 0 0 0 0 0 3 17 0 0 20
A6-HLA-A2-TaxP6A (1qrn) 9 0 0 0 0 26 0 5 12 0 43
A6-HLA-A2-TaxV7R (1qse) 9 1 0 0 0 19 0 12 14 0 46
A6-HLA-A2-TaxY8A (1qsf) 9 4 0 0 0 15 0 1 0 0 20
1G4-HLA-A2-ESO9C (2bnr) 9 0 0 0 24 1 56 2 8 10 0 100
1G4-HLA-A2-ESO9V (2bnq) 9 0 0 0 24 60 2 9 10 0 105
P1 P2 P3 P4 P5 2 P10 P11 P12 P13
SB27-HLA-B3508-EBV (2ak4) 13 0 0 0 8 32 0 0 0 0 40
Human/mouse class II P-4 P-3 P-2 P-1 P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12 P13
172.10/I-A u /MBP (1u3h) 12 0 2 0 0 0 0 8 0 5 1 0 0 16
HA1.7/HLA-DR4/HA (1j8h) 13 0 4 0 2 7 0 3 0 0 9 0 0 0 25
HA1.7/HLA-DR1/HA (1fyt) 13 0 6 0 2 4 0 7 0 0 9 0 0 0 28
Ob.1A12/HLA-DR2b/MBP (1ymm) 14 2 0 2 9 0 7 10 0 9 0 0 0 0 0 39
3A6-HLA-DR2a-MBP (1zgl) 14 6 0 3 0 10 0 1 2 0 9 0 0 1 0 32
scD10/I-A k /CA (1d9k) 16 0 0 1 0 11 0 0 9 0 4 7 0 0 0 0 32