Rudolph MG

Annu. Rev. Immunol. 2006.24:419-466. Downloaded from arjournals.annualreviews.org
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Figure 10
Conserved contacts formed between TCR residues and MHC. The TCR Cα backbone is shown for
three different class I TCRs (left column) and three different class II TCRs (right column), with one TCR
repeated on the bottom of each column. On each of the top three TCRs in each column, spheres are
placed at Cα positions of residues that contact MHC. The spheres are drawn so that their diameters are
in proportion to their actual numbers of contacts to TCR (thus, the large spheres represent residues with
the most contacts). The numbers of contacts are listed in Tables 7 and 8 for TCR residues. The
“conserved” contacts for TCRs of each class are shown as spheres representing the average number of
contacts for each residue (bottom row).
450 Rudolph· Stanfield· Wilson