Understanding Hair Transplants and Hair Loss - Pacific Hair

growth in vitro in dermal papilla cells. IGF-1 is essentially growth hormone, and so
the question presents itself whether or not using perhaps a double dose of growth
hormone on patients for two or three months after a hair transplant would get the
hairs growing a lot sooner . Perhaps it would eliminate the hair shock and three
months of telogen, which is commonly experienced . That therapy could be systemic
or topical . Research will need to be done with this .
7) Similarly, topical T3 solution postop may also contribute to a shortening of the telogen
phase or its elimination . Another recent report has suggested that there may
be little or no type 2 5-alpha reductase located in occipital (donor) dermal papilla
cells . Of course this would explain, if true, why occipital dermal papilla cells are
relatively impervious to the effects of DHT, since most DHT is located intracellular
and not in the circulation. It may be that there are very low levels of DHT in these
cells due to the lack of 5-alpha reductase type 2. It may also be that testosterone,
not DHT, is the stimulator for the growth factors in these cells .
8) Dr. Perez- Mesa, et al. found that growth factor activity appeared as follows following
hair transplantation:
TGFA appeared on day 1, others appeared on day 3 . Growth factors increased on
days 7 through 21. By day 28, EGF and BEGF were the only ones present.
Three phases of revascularization of hair grafts were seen:
1) Plasmatic imbibition at days 1 to 3 .
2) Primary inosculation and growth of blood vessels .
3) Secondary inosculation/neovascularization with changes in the vessels
including the lymphatics . These changes took place simultaneously with
the increase in growth factors .
The study showed that after the hair graft takes and survives, the process
may continue with one of the following scenarios:
a) The hair will continue to grow in anagen phase from day one with
no hair loss .
b) The hair will fall out from one to six weeks postop (anagen effluvium)
with new hairs beginning to grow two to four weeks later .
c) The hair will fall out from seven to twelve weeks postop (telogen
U n d e r s t a n d i n g H a i r T r a n s p l a n t s a n d H a i r L o s s
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