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MLPCN • Molecular Libraries Probe Production Center Network (MLPCN) • Molecular Libraries Small Molecule Repository (MLSMR) maintains a collection that is shared by all centers in the network • HTS and SAR data released into PubChem database Counter screen information • Generate knowledge relevant to human health Target validation Tool compounds for untargeted proteins and classes Starting points for drug discovery
Specifics of MLPCN projects • MLPCN centers funded by NIH Common Fund • PIs access the network through MLPCN grants; the applications require working primary assays • Part of Center’s budget allocated to outreach MLPCN Assignments & Funds MLPCN Center R03/X01 Outreach 12-18 mos PubChem PIs
Page 1 and 2: HTRF Symposium Avignon, France Apri
Page 3 and 4: • SBMRI and CPCCG • NIH Roadmap
Page 5 and 6: Development of Sanford-Burnham Medi
Page 7 and 8: Sanford-Burnham’s Discovery Resea
Page 9 and 10: Conrad Prebys Center for Chemical G
Page 11: Sanford-Burnham uHTS Facility (Orla
Page 15 and 16: MLPCN screening at CPCCG Detection
Page 17 and 18: MLPCN UBL projects performed at CPC
Page 19 and 20: SUMO PPI project • PI: Yuan Chen,
Page 21 and 22: Assay design for SUMO PPI project B
Page 23 and 24: SUMO-PPI MLPCN screening project
Page 25 and 26: SUMOylation project: HTRF Assay GST
Page 27 and 28: SUMOylation project: Probe compound
Page 29 and 30: • Assay Reagents: Assay captures
Page 31 and 32: R a tio (5 2 0 /4 9 0 )x 1 0 0 0 0
Page 33 and 34: Z' factor CUL1 neddylation project
Page 35 and 36: MLN4924 has a complex mechanism of
Page 37 and 38: Concluding remarks • HTRF approac

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