Sanford-Burnham

More documents

Recommendations

Info

SUMO and human health Breast, lung and skin cancers Metastasis hypoxia SUMO E1, E2, E3 isopeptidase Prostate Cancer, Angiogenesis SUMO SIM Protein-1 Protein-2 Most SUMO-dependent functions SUMO Protein-1 ~5-10% of genome P53 Histone HDAC Cyclins … Viral proteins HCMV IE1 &IE2 HIV P6-Gag …
SUMO PPI project • PI: Yuan Chen, PhD (City of Hope, Duarte, CA) Protein-1 SUMO SIM Protein -2 SUMO1-PIAS2 peptide complex Song J, Zhang Z, Hu W, Chen Y, J Biol Chem (2005) 280: 40122
Page 1 and 2: HTRF Symposium Avignon, France Apri
Page 3 and 4: • SBMRI and CPCCG • NIH Roadmap
Page 5 and 6: Development of Sanford-Burnham Medi
Page 7 and 8: Sanford-Burnham’s Discovery Resea
Page 9 and 10: Conrad Prebys Center for Chemical G
Page 11 and 12: Sanford-Burnham uHTS Facility (Orla
Page 13 and 14: Specifics of MLPCN projects • MLP
Page 15 and 16: MLPCN screening at CPCCG Detection
Page 17: MLPCN UBL projects performed at CPC
Page 21 and 22: Assay design for SUMO PPI project B
Page 23 and 24: SUMO-PPI MLPCN screening project
Page 25 and 26: SUMOylation project: HTRF Assay GST
Page 27 and 28: SUMOylation project: Probe compound
Page 29 and 30: • Assay Reagents: Assay captures
Page 31 and 32: R a tio (5 2 0 /4 9 0 )x 1 0 0 0 0
Page 33 and 34: Z' factor CUL1 neddylation project
Page 35 and 36: MLN4924 has a complex mechanism of
Page 37 and 38: Concluding remarks • HTRF approac

Sanford-Burnham

Create successful ePaper yourself

Delete template?

Save as template?