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UBL Cycle UBL GlyGly ATP PP i UBL O GlyGly AMP Cys-SH E1 O UBL GlyGly S E2 “Activation” E1 E1 Cys-SH HS-Cys UBL GlyGly O O - “Conjugation” DUB/ SENP UBL GlyGly O NH Lys E3 UBL GlyGly O S E2 Biological effects S “Ligation” S Lys-NH2
MLPCN UBL projects performed at CPCCG √ √ √ Projects Polyubiquitination SUMOylation Neddylation SUMO-PPI Senp1/CFP-SUMO1-YFP Senp6/Z-RLRGG-AL Senp7/Z-RLRGG-AL Senp8/Z-RLRGG-AL Senp8/Nedd8-AMC Rpn11 Csn5 PIs Dr. John Reed (SBMRI, La Jolla, CA) Dr. Yuan Chen (City of Hope, Duarte, CA) Dr. Matt Petroski (SBMRI, La Jolla, CA) Dr. Yuan Chen (City of Hope, Duarte, CA) Dr. Jorge A. Iniguez-Lluhi (U. Michigan, Ann Arbor, MI) Dr. Guy Salvesen (SBMRI, La Jolla, CA) Dr. Guy Salvesen (SBMRI, La Jolla, CA) Dr. Guy Salvesen (SBMRI, La Jolla, CA) Dr. Guy Salvesen (SBMRI, La Jolla, CA) Dr. Ray Deschaines (CalTech, Los Angeles, CA) Dr. Ray Deschaines (CalTech, Los Angeles, CA)
Page 1 and 2: HTRF Symposium Avignon, France Apri
Page 3 and 4: • SBMRI and CPCCG • NIH Roadmap
Page 5 and 6: Development of Sanford-Burnham Medi
Page 7 and 8: Sanford-Burnham’s Discovery Resea
Page 9 and 10: Conrad Prebys Center for Chemical G
Page 11 and 12: Sanford-Burnham uHTS Facility (Orla
Page 13 and 14: Specifics of MLPCN projects • MLP
Page 15: MLPCN screening at CPCCG Detection
Page 19 and 20: SUMO PPI project • PI: Yuan Chen,
Page 21 and 22: Assay design for SUMO PPI project B
Page 23 and 24: SUMO-PPI MLPCN screening project
Page 25 and 26: SUMOylation project: HTRF Assay GST
Page 27 and 28: SUMOylation project: Probe compound
Page 29 and 30: • Assay Reagents: Assay captures
Page 31 and 32: R a tio (5 2 0 /4 9 0 )x 1 0 0 0 0
Page 33 and 34: Z' factor CUL1 neddylation project
Page 35 and 36: MLN4924 has a complex mechanism of
Page 37 and 38: Concluding remarks • HTRF approac

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