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MLN4924 has a complex mechanism of action Brownell et al, 2010, Mol cell 37:102-111
Page 1 and 2: HTRF Symposium Avignon, France Apri
Page 3 and 4: • SBMRI and CPCCG • NIH Roadmap
Page 5 and 6: Development of Sanford-Burnham Medi
Page 7 and 8: Sanford-Burnham’s Discovery Resea
Page 9 and 10: Conrad Prebys Center for Chemical G
Page 11 and 12: Sanford-Burnham uHTS Facility (Orla
Page 13 and 14: Specifics of MLPCN projects • MLP
Page 15 and 16: MLPCN screening at CPCCG Detection
Page 17 and 18: MLPCN UBL projects performed at CPC
Page 19 and 20: SUMO PPI project • PI: Yuan Chen,
Page 21 and 22: Assay design for SUMO PPI project B
Page 23 and 24: SUMO-PPI MLPCN screening project
Page 25 and 26: SUMOylation project: HTRF Assay GST
Page 27 and 28: SUMOylation project: Probe compound
Page 29 and 30: • Assay Reagents: Assay captures
Page 31 and 32: R a tio (5 2 0 /4 9 0 )x 1 0 0 0 0
Page 33: Z' factor CUL1 neddylation project
Page 37 and 38: Concluding remarks • HTRF approac

Sanford-Burnham

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