Sanford-Burnham

More documents

Recommendations

Info

SUMOylation project: HTS • Primary HTS (PubChem AID 2006) • 291K-compound MLSMR collection • Hits profiled against PubChem data • Secondary assays: • HTRF interference assay (PubChem AID 2069) • ALPHAscreen SUMOylation (PubChem AID 2018) • TR-FRET Ubiquitination (PubChem AID 2658) • PubChem Summary AID 2011 Sharon Colayco, Ekaterina Bobkova, PhD Justin Rascon, Carlton Gasior, Fu-Yue Zeng, PhD
SUMOylation project: Probe compound • The probe compound kills cancer cells • The probe specifically inhibits SAE in the cells Baozong Li, PhD, Yi-Jia Li, PhD, Yuan Chen, PhD
Page 1 and 2: HTRF Symposium Avignon, France Apri
Page 3 and 4: • SBMRI and CPCCG • NIH Roadmap
Page 5 and 6: Development of Sanford-Burnham Medi
Page 7 and 8: Sanford-Burnham’s Discovery Resea
Page 9 and 10: Conrad Prebys Center for Chemical G
Page 11 and 12: Sanford-Burnham uHTS Facility (Orla
Page 13 and 14: Specifics of MLPCN projects • MLP
Page 15 and 16: MLPCN screening at CPCCG Detection
Page 17 and 18: MLPCN UBL projects performed at CPC
Page 19 and 20: SUMO PPI project • PI: Yuan Chen,
Page 21 and 22: Assay design for SUMO PPI project B
Page 23 and 24: SUMO-PPI MLPCN screening project
Page 25: SUMOylation project: HTRF Assay GST
Page 29 and 30: • Assay Reagents: Assay captures
Page 31 and 32: R a tio (5 2 0 /4 9 0 )x 1 0 0 0 0
Page 33 and 34: Z' factor CUL1 neddylation project
Page 35 and 36: MLN4924 has a complex mechanism of
Page 37 and 38: Concluding remarks • HTRF approac

Sanford-Burnham

Create successful ePaper yourself

Delete template?

Save as template?