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CDC Article-US Medical Eligibility Criteria for Contraceptive Use, 2010

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38 MMWR June 18, <strong>2010</strong><br />

TABLE. (Continued) Classifications <strong>for</strong> progestin-only contraceptives,* † including progestin-only pills, DMPA, and implants<br />

Category<br />

Condition<br />

Rheumatic Diseases<br />

POP DMPA Implants<br />

Clarifications/Evidence/Comments<br />

Systemic lupus erythematosus (SLE) §<br />

Persons with SLE are at increased risk <strong>for</strong> ischemic heart disease, stroke, and VTE. Categories assigned to such conditions in the MEC should be the same <strong>for</strong> women with<br />

SLE who present with these conditions. For all categories of SLE, classifications are based on the assumption that no other risk factors <strong>for</strong> cardiovascular disease are present;<br />

these classifications must be modified in the presence of such risk factors.<br />

Many women with SLE can be considered good candidates <strong>for</strong> most contraceptive methods, including hormonal contraceptives (117–135).<br />

a. Positive (or unknown) antiphospholipid<br />

Initiation Continuation Evidence: Antiphospholipid antibodies are associated<br />

antibodies<br />

3 3 3 3<br />

with a higher risk <strong>for</strong> both arterial and venous thrombosis<br />

(136,137).<br />

b. Severe thrombocytopenia 2 3 2 2 Comment: Severe thrombocytopenia increases the risk <strong>for</strong><br />

bleeding. POCs might be useful in treating menorrhagia in<br />

women with severe thrombocytopenia. However, given the<br />

increased or erratic bleeding that may be seen on initiation<br />

of DMPA and its irreversibility <strong>for</strong> 11–13 weeks after administration,<br />

initiation of this method in women with severe<br />

thrombocytopenia should be done with caution.<br />

c. Immunosuppressive treatment 2 2 2 2<br />

d. None of the above 2 2 2 2<br />

Rheumatoid arthritis<br />

a. On immunosuppressive therapy 1 2/3 1 Clarification: DMPA use among women on long-term<br />

b. Not on immunosuppressive<br />

therapy<br />

1 2 1<br />

corticosteroid therapy with a history of, or with risk factors<br />

<strong>for</strong>, nontraumatic fractures is classified as Category 3.<br />

Otherwise, DMPA use <strong>for</strong> women with rheumatoid arthritis is<br />

classified as Category 2.<br />

Evidence: Limited evidence shows no consistent pattern of<br />

improvement or worsening of rheumatoid arthritis with use<br />

of oral contraceptives (138–143), progesterone (144), or<br />

estrogen (145).<br />

Neurologic Conditions<br />

Headaches Initiation Continuation Initiation Continuation Initiation Continuation Clarification: Classification depends on accurate diagnosis<br />

a. Non-migrainous<br />

(mild or severe)<br />

1 1 1 1 1 1 of severe headaches that are migrainous and headaches<br />

that are not. Any new headaches or marked changes in<br />

headaches should be evaluated. Classification is <strong>for</strong> women<br />

without any other risk factors <strong>for</strong> stroke. Risk <strong>for</strong> stroke<br />

increases with age, hypertension, and smoking.<br />

b. Migraine<br />

i. Without aura<br />

• Age

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