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ast one year after<br />

he primary outcome<br />

lity without apical<br />

response to thermal<br />

Jnosed if the apical<br />

as in other parts of<br />

rvers independently<br />

vas defined as the<br />

1 pretreatment pain<br />

'come measure was<br />

:ig. 6, bottom), the<br />

ency.<br />

Results (Study Ill)<br />

Excavation trial<br />

314 patients were randomized. The stepwise excavation group had a significantly<br />

higher success rate (74.1%) at 1-year follow-up (median 476.5 days) compared with<br />

the direct complete excavation group (62.4%) (P = 0.044). The pulp was exposed in<br />

25 teeth (17.5%) after stepwise excavation and in 43 teeth (28.9%) after direct<br />

complete excavation (Table 2).<br />

Rundomizi..-2.4) 11.7ro.5:1".5) 0.044<br />

43 (18.9) -11 A (-21.3: -l.2) 0.030<br />

1 (l.3) II.I 1-:\.5: 3-81 0.665<br />

4 (2.7i -l.3 {-5.:5: 181 0.711<br />

7 (4.7) 0.9 (-··U: 6.Xl 0.934<br />

~ria (11 =49)<br />

+5i<br />

i a; i.mot!wr clinic 32)<br />

Table 2. Outcome measure analysis of teeth at follow-up (Source: Table 2, Study Ill. Reprinted with<br />

permission from European Journal of Oral Sciences, Wiley-Blackwell, Oxford).<br />

•hloj (n "'SJ<br />

out randamiza1ia1?) (n "~ 5)<br />

Prognostic factors<br />

Patients with pretreatment pain were significantly less likely to show a successful<br />

treatment result at follow-up compared to those without pain, when adjusting for the<br />

effect of treatment, age, and centre. Treatment of patients younger than 50 years<br />

(median for the group: 28 years) was more likely to result in sustained pulp vitality<br />

without apical radiolucency than following treatment of older patients (median age of<br />

the group: 58 years); however, only borderline significance was noted. The odds<br />

ratios of pulp exposure differed among the centres, with centres 1 and 2 significantly<br />

more often avoiding pulp exposure (adjusted for the effect of treatment, age and<br />

pain).<br />

llocation, follow-up and<br />

printed with permission<br />

19

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