Quattro 2 User's Guide, issue 2. 6666533 - Waters

Quattro II
User's Guide
The Direct GC Inlet
The capillary column inlet line consists of stainless steel tubing, the bore of which is
large enough to allow fused silica capillary columns to be fed from the GC oven
directly into the ion source. The end of the column reaches to within a few
millimetres of the ion beam.
Other types of capillary column may be connected to a short length of fused silica
capillary, using zero dead-volume connectors. The fused silica passes through the GC
inlet into the ion source
The Jet Separator Inlet
When packed GC columns (or wide bore capillary columns at high flow rates) are to
be used, then the column eluent is passed into the ion source via the optional jet
separator. The jet separator reduces to acceptable levels the flow of carrier gas into the
mass spectrometer while increasing the concentration of sample molecules in the
eluent reaching the source.
The Particle Beam LC-MS Interface
Ion Optics
By passing the HPLC eluent in turn through a pneumatic nebuliser, a desolvation
chamber and a momentum separator to remove solvent, a stream of sample particles is
produced.
These particles then enter the standard EI/CI source for analysis. In the case of EI,
library-searchable spectra are produced.
The particle beam interface will cope with HPLC flow rates of up to approximately
1 ml/min.
The Quattro II is a tandem quadrupole mass spectrometer for MS and MS-MS
analysis. The principle components of the ion optical system are shown in schematic
form below.
Instrument Description
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