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Pediatric Terrorism and Disaster Preparedness: A ... - PHE Home

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Table 6.10. Radionuclide specific therapies<br />

Radionuclide Therapy Mechanism of action<br />

Iodine KI Blocks thyroid deposition<br />

Cesium/Rubidium/Thallium Prussian blue<br />

Blocks GI absorption <strong>and</strong> prevents<br />

recycling<br />

Plutonium <strong>and</strong> transuranics DTPA<br />

Acts as chelating agent<br />

(Americium, Californium,<br />

Lanthanum, Curium)<br />

Uranium Bicarbonate Alkalinizes urine, decreases<br />

chances of acute tubular necrosis<br />

Tritium Forced fluids, diuretics Dilutes isotope<br />

Strontium<br />

Oral aluminum phosphate Blocks GI absorption<br />

or barium sulfate<br />

Radium<br />

Magnesium sulfate lavage Prevents absorption<br />

Phosphorus<br />

Stomach lavage, aluminum Prevents absorption, blocks<br />

hydroxide, oral phosphates cellular deposition<br />

Cobalt<br />

Gastric lavage, purgatives; Prevents absorption, acts as<br />

penicillamine if severe chelating agent<br />

Source: National Council on Radiation Protection <strong>and</strong> Measurements. Management of Persons Accidentally<br />

Contaminated with Radionuclides. Report Number 65, 1979. Bethesda, MD. Reprinted with permission.<br />

235

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