4. Clinical Guidelines for Liver Transplantation (PDF) - British ...

Guidebook for the Solid Organ Transplant Programme Chapter 4
Appendix D
Target Cyclosporine Blood Concentrations for Liver Transplant Recipients
As of June 2010, in British Columbia there are two different types of assays used for the determination of
Cyclosporine blood concentrations:
1. Immunoassay (Abbott TDX ® )
2. Mass Spectrometry Assay.
Mass spectrometry results are 24% lower than the Abbott TDX Assay.
You must know which assay was used for measuring the Cyclosporine concentrations to interpret the
result. There is a chart below which lists the assays used to monitor Cyclosporine concentrations at different
hospitals in the province.
Time Post
Transplant
(Months)
Cyclosporine
Trough
Concentration
(ng/mL)
Immunoassay
Cyclosporine C 2
(ng/mL)
Immunoassay
Cyclosporine Trough
Concentration
(ng/mL)
Mass Spectrometry
Assay
Cyclosporine C 2
(ng/mL)
Mass
Spectrometry
Assay
0 to 3 300 to 350 1000 250 to 275 750
3 to 6 250 to 300 800 200 to 250 600
6 to 9 200 to 250 600 150 to 200 450
9 to 12 150 to 200 600 125 to 150 450
Greater than 12 125 to150 600 100 to 125 450
Prepared by Nilu Partovi, Pharm D. March 10, 2004
Target Trough Tacrolimus Blood Concentrations for Liver Transplant Recipients
As of June 2010, in British Columbia there are two different types of assays used for the determination
of Tacrolimus blood concentrations:
1. Immunoassay (Abbott TDX ® )
2. Mass Spectrometry Assay.
Mass spectrometry results are 24% lower than the Abbott TDX Assay.
You must know which assay was used for measuring the Tacrolimus concentrations to interpret
the result. There is a chart below which lists the assays used to monitor Tacrolimus concentrations at
different hospitals in the province.
Time Post-
Transplant
(Months)
Tacrolimus Trough
Blood Concentration
(ng/mL)
12 hours Post-Dose
Immunoassay
Tacrolimus Trough Blood
Concentration (ng/mL)
12 hours Post-Dose
Mass Spectrometry Assay
Less than 1 10 to 15 8 to 12
1 to 3 8 to 12 6 to 9
Greater than 3 5 to 10 4 to 8
For Liver Transplant Patients With Hepatitis C or Renal Failure
Less than 1 8 to 12 6 to 9
1 to 3 5 to 10 4 to 8
Greater than 3 5 to 10 4 to 8
Chapter 4 – Clinical Guidelines for Liver Transplantation – July, 2010 Page 44
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