Drug-Resistant Malaria - libdoc.who.int - World Health Organization

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lO~ Mr W. Rooney Laboratory Specialist Intercountry Project ICP/MPD/OOl New Delhi, India WHO, Western Pacific Region Dr C.T. Ch'en Regional <strong>Malaria</strong> Adviser Manila, Philippines Dr G. Farid Medical Officer Special Programme for Research and Training in Tropical Diseases Manila, Philippines Mr J. Storey Technical Officer (Parasitology) Regional Antimalaria Team Kuala Lumpur, Malaysia
APPENDIX 2 List of Documents A. WORKING PAPERS Document Number Resistance of malaria parasites to drugs in the context of the malaria action programme; studies to be undertaken in this respect to better define a realistic policy for the future. Dr T. LEPES Chloroquine resistance studies in Papua New Guinea. Dr 1.5. DULAY Progress and planning report Bangladesh Progress and planning report Burma Progress and planning report India Progress and planning report Indonesia Progress and planning report Nepal Progress and planning report Sri Lanka MAL/DRUG/8l.WP.l (HQ) MAL/DRUG/8l/WP.la (WPRO) MAL/DRUG/8l.WP.la, (SEARO) MAL/DRUG/8l/WP.lb (SEARO) MAL/DRUG/81/WP.lc (SEARO) MAL/DRUG/81/WP.ld (SEARO) MAL/DRUG/8l/WP.le (SEARO) MAL/DRUG/8l/WP.lf (SEARO)
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Drug-Resistant Malaria The Report o
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Foreword A meeting on drug-resistan
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CONTENTS Page Drug Pressure and Res
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2 / INTRODUCTION Differences in dru
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II. Opening Address and Messages Ol
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OPENING ADDRESS / 7 phical boundari
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OPENING ADDRESS / 9 to preserve for
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OPENING ADDRESS / 11 is also here a
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Ill. Review of Drug Resistance in P
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REVIEW I 15 Table 1. Sensitivity Te
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REVIEW / 17 Other Studies Validatio
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Distribution of Chloroquine-Resista
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REVIEW I 21 are signs to suggest th
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REVIEW / 23 (h) specialized investi
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REVIEW / 25 TABLE 3~ Comparison of
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REVIEW / 27 Of 22 mefloquine in vit
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REVIEW / 29 operational conditions
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REVIEW / 31 the possible influence
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IV. Monitoring of Drug Response of
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MONITORING / 35 during recent years
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MONITORING / 37 India, Sri Lanka an
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Table 4. Results of Micro In Vitro
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MONITORING / 41 The superiority of
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MONITORING / 43 input of the result
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MONITORING / 45 table time 1ag and
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Table 6. Probability of Detecting t
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MONITORING / 49 prevalence = 10% an
Page 59: MONITORING / 51 TDR. At the end of
Page 62 and 63: 54 / RESEARCH RESULTS characteristi
Page 64 and 65: 56 / RESEARCH RESULTS EXO-ERYTHROCY
Page 67 and 68: VI. Control of Drug-Resistant P. fa
Page 69 and 70: CONTROL / 61 DRUG USE AIMING AT PRE
Page 71 and 72: Table 7. Specific Actions for the C
Page 73 and 74: CONTROL / 65 Table 8. Drugs or Comb
Page 75 and 76: Table 9. Suggested Use of Antimalar
Page 77 and 78: Table 9. Suggested Use of Antimalar
Page 79 and 80: CONTROL / 71 Radical therapy of mic
Page 81 and 82: CONTROL / 73 Tanzania several years
Page 83 and 84: VII. Field and Laboratory Research
Page 85 and 86: RESEARCH FOR CONTROL / 77 In vivo a
Page 87 and 88: RESEARCH FOR CONTROL / 79 migrants
Page 89 and 90: RESEARCH FOR CONTROL / 81 and Phase
Page 91: RESEARCH FOR CONTROL / 83 (b) Metho
Page 94 and 95: 86 / RECOMMENDATIONS and sulfonamid
Page 96 and 97: 88 / RECOMMENDATIONS (xiii) Simple
Page 99 and 100: IX. Summary The Meeting on Drug-Res
Page 101 and 102: APPENDIX 1 List of Participants, Ob
Page 103 and 104: APPENDICES / 95 Sri Lanka Dr M.K. B
Page 105 and 106: APPENDICES / 97 Papua New Guinea Dr
Page 107 and 108: APPENDICES / 99 TEMPORARY ADVISERS
Page 109: APPENDICES / 101 Dr L.E. Molineaux
Page 113 and 114: APPENDICES / 105 Comparative study
Page 115 and 116: APPENDIX 3.1 I 107 RESPONSE OF Plas
Page 117: APPENDIX 3.2 / 109 RESPONSE OF P. F
Page 120 and 121: 112 / APPENDICES 0.25 0.50 0.75 1.0
Page 122 and 123: 114 / APPENDICES Chloroquine is eff
Page 124 and 125: 116 / APPENDICES 1.4 Sulfonamide pl
Page 126 and 127: 118 / Various tetracycline analogs
Page 128 and 129: 120 / APPENDICES A loading dose on
Page 130 and 131: 122 / APPENDICES The drug should be
Page 132 and 133: 124 / APPEND ICE S 2. INDICATIONS f
Page 134 and 135: 126 / APPENDICES they are already r
Page 136 and 137: 128 / APPENDICES 5.2 In suppressive
Page 138 and 139: 130 / APPENDICES Outline research p
Page 140 and 141: 132 / APPENDICES Long-term To preve
Page 143 and 144: APPENDIX 8 Considerations Related t
Page 145 and 146: APPENDICES / 137 4. Screening point
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