Drug-Resistant Malaria - libdoc.who.int - World Health Organization
Drug-Resistant Malaria - libdoc.who.int - World Health Organization
Drug-Resistant Malaria - libdoc.who.int - World Health Organization
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REVIEW / 17<br />
Other Studies<br />
Validation and development studies were carried out on the<br />
micro in vitro test on the response of P.falciparum to antimalarial<br />
drugs. Studies using this technique with chloroquine were<br />
conducted in Burma, India, Indonesia, Sri Lanka and Thailand. In<br />
Sri Lanka the technique was used to compare the response to<br />
chloroquine and amodiaquine, while in Thailand it was employed to<br />
study the response to chloroquine, quinine and mefloquine.<br />
In Burma studies on the drug combinations sulfadoxinepyrimethamine<br />
and sulfalene-pyrimethamine have indicated that both<br />
combinations produce similar clinical results although with a<br />
higher number of early recrudescences in the suI falene/pyrimethamine<br />
group. A small percentage of patients included 1n the<br />
studies failed to respond a priori.<br />
A scientist from Thailand was given the opportunity of<br />
visiting Sri Lanka to collect P.falciparum isolates for<br />
characterization studies. Using the continuous culture method the<br />
isolates have been shown to be highly sens1t1ve to chloroquine,<br />
amodiaquine, quinine, pyrimethamine and mefloquine.<br />
Under a research grant, a scientist at Chiengmai University,<br />
Thailand, has commenced a study on the metabolic fate of sulfadoxine<br />
and on the correlation between the host's metabolic activity<br />
and the effect of the sulfadoxine/pyrimethamine combination.<br />
A scientist of the Department of Medical Research, Rangoon,<br />
Burma, was given the opportunity of carrying out a comparative<br />
study of the in vivo and in vitro micro tests for the response of<br />
P.falciparum to chloroquine.<br />
Coordination<br />
The Regional Office has continued to provide coordination and<br />
technical guidance and to assist in training and in the planning<br />
of studies. Exchange of information between the countries 1S<br />
arranged by the Regional Office through correspondence and by<br />
conducting review meetings. These review meetings are planned on<br />
a bi-annual basis.<br />
Training<br />
National training has been stepped up 1n Indonesia with the<br />
assistance of a WHO team. This has enabled the country to expand<br />
the number of monitoring teams. In India further training was<br />
postponed for various reasons, but a priority programme is being<br />
developed to <strong>int</strong>roduce the micro in vitro technique. An increase<br />
of the monitoring teams from 6 to 12 has been envisaged.