Drug-Resistant Malaria - libdoc.who.int - World Health Organization

APPENDICES / 119
effective, prophylaxis needs to be continued for at least 4 weeks,
better still, 6 weeks after exposure. 1
3.1 Chloroquine
See section 1.1 for chemical name,
formulations.
trade names and
Regimen:
Adults 300 mg (or 5 mg/kg) weekly
Children:up to 1 year 37.5 - 50 mg (5 mg/kg) weekly
1-4 years 50 - 100 mg (5 mg/kg) weekly
5-8 years 150 - 200 mg (5 mg/kg) weekly
9-12 years 200 - 300 mg (5 mg/kg) weekly
A loading dose of 300 mg for adults or 5 mg/kg in the younger
age groups, given on the second day of prophylaxis is
recommended. It will provide effective blood concentrations
earlier.
Chloroquine is highly effective as a suppressive chemoprophylactic
drug for falciparum malaria and side effects are uncommon
at the recommended dosage regimen. It may be used safely in
children and pregnart women. While a therapeutic regimen for an
acute attack may be tolerated by patients with impaired renal
function, a reduced dosage regimen may have to be employed for
long term prophylaxis. Retinophathy is a function of the total
administered dose and may appear if a total dose in excess of 100
g is administered over 2 1/2 to 6 1/2 years.
3.2 Amodiaquine
See section 1.2 for chemical name,
formulations.
trade names and
Regimen:
Adults
400 mg weekly
Children : up to 1 year 50 mg weekly
1-4 years 50-100 mg weekly
5-8 years 150-200 mg weekly
9-12 years 200-300 mg weekly
1
The use of proguanil or pyrimethamine alone for chemoprophylaxis
is not recommended in view of the very widespread resistance
to DHFR inhibitors of P.falciparum and P.vivax throughout
the world.