Drug-Resistant Malaria - libdoc.who.int - World Health Organization

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122 / APPENDICES The drug should be administered according as for adults and at the fraction of the nearest body weight. to the same schedule adult dose for the 5.2.2 Fractional dose per kilogram method The drug should schedule as for adults equivalent to the adult be administered according and at a dose per kilogram dose divided by 50. to the same of body weight
APPENDIX 6 Future Deployment of Mefloquine and Essential Measures for Protecting Mefloquine Against Resistance By W. P"eters Department of Medical Protozoology London School of Hygiene and Tropical Medicine Keppel Street, London WClE 7HT, England 1. INTRODUCTION Detailed accounts of the chemical and pharmacological properties of mefloquine were presented at a recent meeting of the Scientific Working Group on the Chemotherapy of <strong>Malaria</strong> of the UNDP/<strong>World</strong> Bank/WHO Special Progrannne on Research and Training in Tropical Diseases. For the purpose of this annex the following aspects of mefloquine should be borne in mind;- action restricted to asexual blood stages (and developing gametocytes? ) no action on mature gametocytes of Plasmodium falciparum no action on tissue schizonts of any species, nor on mosquito stages no action on secondary tissue stages of P.vivax and P.ovale (hypnozoites?) blood schizontocidal action present against all Plasmodium species
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Drug-Resistant Malaria The Report o
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Foreword A meeting on drug-resistan
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CONTENTS Page Drug Pressure and Res
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2 / INTRODUCTION Differences in dru
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II. Opening Address and Messages Ol
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OPENING ADDRESS / 7 phical boundari
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OPENING ADDRESS / 9 to preserve for
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OPENING ADDRESS / 11 is also here a
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Ill. Review of Drug Resistance in P
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REVIEW I 15 Table 1. Sensitivity Te
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REVIEW / 17 Other Studies Validatio
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Distribution of Chloroquine-Resista
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REVIEW I 21 are signs to suggest th
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REVIEW / 23 (h) specialized investi
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REVIEW / 25 TABLE 3~ Comparison of
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REVIEW / 27 Of 22 mefloquine in vit
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REVIEW / 29 operational conditions
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REVIEW / 31 the possible influence
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IV. Monitoring of Drug Response of
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MONITORING / 35 during recent years
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MONITORING / 37 India, Sri Lanka an
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Table 4. Results of Micro In Vitro
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MONITORING / 41 The superiority of
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MONITORING / 43 input of the result
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MONITORING / 45 table time 1ag and
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Table 6. Probability of Detecting t
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MONITORING / 49 prevalence = 10% an
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MONITORING / 51 TDR. At the end of
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54 / RESEARCH RESULTS characteristi
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56 / RESEARCH RESULTS EXO-ERYTHROCY
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VI. Control of Drug-Resistant P. fa
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CONTROL / 61 DRUG USE AIMING AT PRE
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Table 7. Specific Actions for the C
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CONTROL / 65 Table 8. Drugs or Comb
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Table 9. Suggested Use of Antimalar
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Table 9. Suggested Use of Antimalar
Page 79 and 80: CONTROL / 71 Radical therapy of mic
Page 81 and 82: CONTROL / 73 Tanzania several years
Page 83 and 84: VII. Field and Laboratory Research
Page 85 and 86: RESEARCH FOR CONTROL / 77 In vivo a
Page 87 and 88: RESEARCH FOR CONTROL / 79 migrants
Page 89 and 90: RESEARCH FOR CONTROL / 81 and Phase
Page 91: RESEARCH FOR CONTROL / 83 (b) Metho
Page 94 and 95: 86 / RECOMMENDATIONS and sulfonamid
Page 96 and 97: 88 / RECOMMENDATIONS (xiii) Simple
Page 99 and 100: IX. Summary The Meeting on Drug-Res
Page 101 and 102: APPENDIX 1 List of Participants, Ob
Page 103 and 104: APPENDICES / 95 Sri Lanka Dr M.K. B
Page 105 and 106: APPENDICES / 97 Papua New Guinea Dr
Page 107 and 108: APPENDICES / 99 TEMPORARY ADVISERS
Page 109 and 110: APPENDICES / 101 Dr L.E. Molineaux
Page 111 and 112: APPENDIX 2 List of Documents A. WOR
Page 113 and 114: APPENDICES / 105 Comparative study
Page 115 and 116: APPENDIX 3.1 I 107 RESPONSE OF Plas
Page 117: APPENDIX 3.2 / 109 RESPONSE OF P. F
Page 120 and 121: 112 / APPENDICES 0.25 0.50 0.75 1.0
Page 122 and 123: 114 / APPENDICES Chloroquine is eff
Page 124 and 125: 116 / APPENDICES 1.4 Sulfonamide pl
Page 126 and 127: 118 / Various tetracycline analogs
Page 128 and 129: 120 / APPENDICES A loading dose on
Page 132 and 133: 124 / APPEND ICE S 2. INDICATIONS f
Page 134 and 135: 126 / APPENDICES they are already r
Page 136 and 137: 128 / APPENDICES 5.2 In suppressive
Page 138 and 139: 130 / APPENDICES Outline research p
Page 140 and 141: 132 / APPENDICES Long-term To preve
Page 143 and 144: APPENDIX 8 Considerations Related t
Page 145 and 146: APPENDICES / 137 4. Screening point
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