Drug-Resistant Malaria - libdoc.who.int - World Health Organization

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has been recognized. In the field of malaria, the administration
of spec ific drugs is not yet in tune with clinical pharmacological
requirements and knowledge of the latter is sti1l scanty. Moreover,
pharmacokinetics and pharmacodynaaamics may differ within
the same patient.
Studies 1n Thai children with multiresistant P.fa1c~~~
infections and treated with quinine for 14 days at 10 mg quinine/kg
body weight suggested that peak blood concentrations were reached
within 2 or 3 days and that m1n1mum inhibitory concentrations
(MIC) need to be maintained for at least six days in order to
produce radical cure. This may not be possible with the indicated
dose level since the blood levels tend to fa1l when the fever
disappears. Thus the levels may drop even below the MIC within
one week.