Qualitative and quantitative analysis of biologically active principles ...
Qualitative and quantitative analysis of biologically active principles ...
Qualitative and quantitative analysis of biologically active principles ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Antiinflammatory activity<br />
The administration <strong>of</strong> the root extract inhibited the carragenan<br />
induced acute paw oedema <strong>and</strong> formalin induced chronic paw<br />
oedema in a dose dependent manner (Table 6). The animals treated<br />
with 70 per cent methonolic extract @ 250 mg/kg <strong>and</strong> 500 mg/kg<br />
showed 47.05 <strong>and</strong> 70.58% inhibition <strong>of</strong> carragenan induced acute<br />
inflammation. In the case <strong>of</strong> formalin induced chronic<br />
inflammation, 250 mg/kg <strong>and</strong> 500 mg/kg showed inhibition <strong>of</strong><br />
50.00 <strong>and</strong> 72.00%, respectively (Table 7).<br />
Table 6. Effect <strong>of</strong> Premna serratifolia (70% methanolic extract) on<br />
carrageenan induced paw odema<br />
Initial paw<br />
Groups thickness<br />
(mm)<br />
Control 0.21 ±<br />
0.01<br />
Dichl<strong>of</strong>enac 0.22 ±<br />
0.02<br />
Paw<br />
thickness on<br />
3 hrs (mm)<br />
Increase in<br />
paw<br />
thickness<br />
% <strong>of</strong><br />
inhibition<br />
0.38 ± 0.02 0.17 …….<br />
0.29 ± 0.07 58.82<br />
0.008 a<br />
Premna serratifolia<br />
250 mg/kg body<br />
wt<br />
Premna serratifolia<br />
500 mg/kg body<br />
wt<br />
0.21 ±<br />
0.02<br />
0.20 ±<br />
0.01<br />
0.30 ± 0.09 47.05<br />
0.008 a<br />
0.25 ± 0.05 70.58<br />
0.027 a<br />
Values are Mean ± SD; for six animals in each group; (a) p, 0.01, (b)<br />
p
Change language