Topical tacrolimus in atopic dermatitis: Effects of ... - Helda - Helsinki.fi

of one type of treatment can be better extended to clinical practice, have become
necessary for chronic diseases such as asthma (Bjermer 2006). At present, no such
studies have appeared on AD.
Table 1. Studies on the most common treatments of AD including only those with
efficacy >50%.
Treatment Efficacy in placebo-controlled short-term
studies ( < 6 months)
Topical
steroids
UV-light
treatments
Betamethasone dipropionate (Vanderploeg
1976)
Clobetasol propionate (Maloney et al. 1998)
Desonide (Stalder et al. 1994)
Halcinonide (Lupton et al. 1982)
Hydrocortisone buteprate (Sears et al. 1997)
Hydrocortisone valerate (Sefton et al. 1984)
Fluticasone propionate (Lebwohl et al. 1996)
Fluticasone propionate in maintenance therapy
twice weekly (Berth-Jones et al. 2003)
Broad band UVB (Jekler & Larkö 1988)
Narrow band UVB, UVA (Reynolds et al. 2001)
Ciclosporin 5 mg/kg (Munro et al. 1994, Salek et al. 1993,
Sowden et al. 1991, van Joost et al. 1994,
Wahlgren et al. 1990)
Systemic
steroids
32
Efficacy in controlled long-term studies
( � 6 months)
Fluticasone propionate vs. vehicle in
maintenance therapy twice weekly (Hanifin et al.
2002)
Unavailable
Unavailable Unavailable
Methotrexate Unavailable Unavailable
Azathioprine Unavailable Unavailable
Tacrolimus
ointment
Pimecrolimus
cream
0.03% in children (Schachner et al. 2005)
0.03% in adults and children (Chapman et al.
2005)
0.1% and 0.03% in adults and children (Hanifin
et al. 2001, Paller et al. 2001)
0.03%, 0.1%, and 0.3% in adults and children
(Ruzicka et al. 1997, Boguniewicz et al. 1998)
Adults (Eichenfield et al. 2002)
Children (Ho et al. 2003)
3 mg/kg vs. 5mg/kg (Zonneveld et al. 1996)
Short courses vs. continuous (Harper et al. 2000)
0.1% tacrolimus vs. hydrocortisone 17-butyrate/
hydrocortisone (Reitamo et al. 2005)
Pimecrolimus vs. vehicle in adults, flare control
(Meurer et al. 2002, 2004)
Pimecrolimus vs. vehicle in children, flare control
(Wahn et al. 2002, Kapp et al. 2002, Papp et al.
2004)
Pimecrolimus vs. triamcinolone acetate /
hydrocortisone (Luger et al. 2004) (No intentionto-treat
analysis)