Topical tacrolimus in atopic dermatitis: Effects of ... - Helda - Helsinki.fi

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Staphylococcus aureus colonization By the first week of the treatment, S. aureus colonization and the eczema score decreased markedly. The median decrease in CFU/cm 2 from baseline was 59.1 at week 1 (p=0.012), 102.4 at month 6 (p
Figure 1. Combined levels of PINP and PIIINP in healthy controls and patients treated with corticosteroids or tacrolimus ointment 0.1% monotherapy. Mean ± 95% CI, median, maximum, and minimum of H) healthy controls, N=27; C0) corticosteroidtreated patients, N=36, at baseline, and C12) after 12 months; T0) tacrolimus-treated patients, N=56, at baseline, T12) after 12 months, and T24) after 24 months. Conjunctival cytology In the conjunctival cytology samples, after treatment with tacrolimus ointment a significant decrease occurred in eosinophils (85%, p=0.01), neutrophils (58%, p=0.02), lymphocytes (50%, p=0.01), and squamous cell metaplasia (39%, p=0.04). No change occurred in epithelial, columnar, or goblet cells, nor was any cellular atypia evident. Of ten patients, eight used concomitant eye-drops containing sodium chromoglygate or its derivatives. Respiratory symptoms and findings In Studies III and V, most of the AD patients were SPT-positive. Life-time prevalences of physician-diagnosed asthma and allergic rhinitis were higher than in control subjects, but only a subgroup of patients was currently actively treated (Table 7). 49
Page 1 and 2: Topical tacrolimus in atopic dermat
Page 3: To Juha and Veera
Page 6 and 7: Effects of treatment on skin barrie
Page 8 and 9: ABBREVIATIONS AD Atopic dermatitis
Page 10 and 11: and bronchial hyper-responsiveness
Page 12 and 13: REVIEW OF THE LITERATURE Atopic der
Page 14 and 15: probably plays a protective role ag
Page 16 and 17: e induced by IL-2 and bacterial sup
Page 18 and 19: and has a lower risk for asthma and
Page 20 and 21: Both asthma and allergic rhinitis i
Page 22 and 23: early childhood, and is accompanied
Page 24 and 25: naturally occurring glucocorticoste
Page 26 and 27: severe atopic dermatitis, hand ecze
Page 28 and 29: and their complex inhibits activati
Page 30 and 31: extent of topical absorption decrea
Page 32 and 33: of one type of treatment can be bet
Page 34 and 35: liver (Burgeson & Nimni 1992). At l
Page 36 and 37: UVA therapy suppresses collagen syn
Page 38 and 39: AIMS OF THE STUDY Atopic dermatitis
Page 40 and 41: Inclusion criteria Patients with mo
Page 42 and 43: Methods Treatment with tacrolimus o
Page 44 and 45: Respiratory symptoms and findings T
Page 46 and 47: Statistical methods In Studies I, I
Page 50 and 51: Table 7. Subject characteristics; o
Page 52 and 53: physician-diagnosed asthma (2.09 vs
Page 54 and 55: In Study V, eight (12%) patients us
Page 56 and 57: Skin collagen synthesis The results
Page 58 and 59: Results of the present uncontrolled
Page 60 and 61: al. 1986, Burrows et al. 1989, Kono
Page 62 and 63: ACKNOWLEDGEMENTS This study was car
Page 64 and 65: REFERENCES Aberer W, Wolff K. Syste
Page 66 and 67: Bousquet J; Jeffery PK, Busse WW, J
Page 68 and 69: Dold S, Wjst M, von Mutius E, Reitm
Page 70 and 71: Haapasaari K. Rossi O. Risteli J. O
Page 72 and 73: Krutmann JT, Morita A. Phototherapy
Page 74 and 75: Nishino K, Fukushima A, Okamoto S,
Page 76 and 77: Quanjer PH, Tammeling GJ, Cotes JE,
Page 78 and 79: Schultz-Larsen F, Diepgen T, Svenso
Page 80 and 81: Tsai WC, Pang JH, Hsu CC, Chu NK, L
Page 82: ERRATA Page 36: In Table 2 in the c

Topical tacrolimus in atopic dermatitis: Effects of ... - Helda - Helsinki.fi

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