Use of oxytocin and misoprostol for induction or ... - POPPHI

Thus, excluding extra-amniotic infusion, the non-pharmacological methods discussed
here in general were not associated with adverse maternal or perinatal outcomes and
reduced or showed not difference in the risk of Cesarean section. It is unfortunate that
the only studies which used duration of pregnancy and post-dates as outcome indicators
were the studies assessing sweeping of the membranes, as these two indicators appear to
be more appropriate for non-pharmacological methods than is no vaginal delivery within
24 hours.
iii. Availability and packaging of oxytocin and misoprostol
Oxytocin is widely available throughout the world. It is inexpensive and is available in
the following liquid preparations: 10IU / 1ml ampoule, 10IU 1ml uniject, 10IU / 10ml,
and 50IU / 50ml in a multiuse vial as illustrated below in Figure 3.6b (3). Oxytocin can
require refrigeration, though some formulations can be kept at 15-25 degrees F, it is not
sensitive to light and it is the drug of choice for AMSTL (3). Oxytocin is also the drug of
choice for augmentation of labor and IOL if proper monitoring is available as per three
national guidelines.
Figure 3.6b Oxytocin vials and uniject.
Source: www.appdrugs.com/ProdJPGs/OxytocinLg.jpg
Misoprostol:
Misoprostol is an inexpensive and temperature stable drug, making it well suited to LRS.
The inclusion of misoprostol for obstetric purposes in developing country Ministries of
Health (MOH) essential drug lists has been slow to be accepted in many countries due to
49