Lithium: The Forgotten Wonderdrug

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Episode Recurrence in Bipolar II Disorder – With Lithium • Hypomania – 0.16 recurrence per year – 3.36% of time ill • Depression – 0.56 recurrences per year – 12.6 of time ill Tondo L, Baldessarini RJ, Hennen J, Floris G. Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry. 1998 May;155(5):638-45.
Reduction of Episode Recurrence • Bipolar I with Lithium Treatment – Yearly Episodes > 50% fewer in 56.4% of the patients – More than 50% less time ill in 59% of patients • Bipolar II – Yearly Episodes > 50% fewer in 72.9% of the patients – More than 50% less time ill in 72.9% of patients Tondo L, Baldessarini RJ, Hennen J, Floris G. Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry. 1998 May;155(5):638-45.
Page 1 and 2: Lithium: The Forgotten Wonderdrug W
Page 3: What Is Lithium
Page 7 and 8: History • 1880s to early 1900s li
Page 9 and 10: Psychiatric Uses For Lithium • An
Page 11 and 12: Advantages of Lithium • Well esta
Page 13 and 14: Decline In Lithium Use
Page 15 and 16: Trend in Veterans Affairs Medical C
Page 17 and 18: Lithium Therapy And Suicide Risk In
Page 19 and 20: Suicide Risk in Mood Disorders •
Page 21 and 22: Overall Rates • Suicides and atte
Page 23 and 24: Rates of Suicide Attempts • Suici
Page 25 and 26: Risk Reduction in Diagnostic Subtyp
Page 27 and 28: Other Important Risk Factors in Sui
Page 29 and 30: Limitations of Evidence • Lack of
Page 31 and 32: Rationale For Long Term Treatment W
Page 33 and 34: Relapse in Bipolar Disorder • Des
Page 35 and 36: Episode Recurrence in Bipolar I Dis
Page 37: Episode Recurrence in Bipolar I Dis
Page 41 and 42: Risk vs Benefit Of Lithium Maintena
Page 43 and 44: Potential Toxicity of Long Term Lit
Page 45 and 46: Reducing Risk, Increasing Benefit:
Page 47 and 48: Initiating and Monitoring Lithium T
Page 49 and 50: Initiating Lithium • Prior to ini
Page 51 and 52: Blood Monitoring • Lithium can be
Page 53 and 54: Therapeutic Levels • Upper end: 1
Page 55 and 56: Lithium Discontinuation
Page 57 and 58: Reduced Morbidity After Gradual Dis
Page 59 and 60: Lithium Discontinuation and Subsequ
Page 61 and 62: APA Treatment Guidelines For Bipola
Page 63 and 64: Bipolar Depression • First line t
Page 65 and 66: Maintenance “The medications with

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