Stability of Drugs and Dosage Forms Sumie Yoshioka

198 Chapter 5 • Stability of Peptide and Protein Pharmaceuticals
Figure 206. First-order plots of the degradation of an LH-RH antagonist in aqueous solution at varying pH values
(80°C). (Reproduced from Ref. 802 with permission.)
decay, apparent first-order kinetics (Fig. 208). 879 Apparent inactivation of kallikrein was
described according to a kinetic model representing a reversible and an irreversible reaction
(Eq. 5.1) or an alternative model representing independent irreversible inactivation of two
isoenzymes (Eq. 5.2). 879 (5.1)
Figure 207. First-order plots of the deamidation of calcitonin in aqueous solution at varying pH values (70°C).
(Reproduced from Ref. 876 with permission.)