Stability of Drugs and Dosage Forms Sumie Yoshioka

More documents

Recommendations

Info

2.2. • Factors Affecting Chemical Stability 45 Figure 12. Time courses of epimerization and hydrolysis of etoposide (pH 10, 37°C). (Reproduced from Ref. 157 with permission.) (2.31) (2.32) where
46 Chapter 2 • Chemical Stability of Drug Substances 2.2.3.1.h. Pseudo-First-Order Parallel Reactions k 2 k 1 P, D P, Equations (2.33) and (2.34) pertain when drug D converts to P 1 and P 2 via independent first-order pathways. (2.33) (2.34) Many drugs degrade to more than one product so this scheme is quite common. Often, more than two products are formed. 2.2.3.1.i. Pseudo-First-Order Reversible and Parallel Reactions When both P 1 and P 2 are capable of being converted back to D, Eqs. (2.35) and (2.36) adequately describe the kinetics. (2.35) (2.36)
Page 2 and 3:
Stability of Drugs and Dosage Forms
Page 4 and 5: eBook ISBN: 0-306-46829-8 Print ISB
Page 6 and 7: vi Preface As stated earlier, this
Page 8 and 9: viii Contents 2.2.4.2. Quantitation
Page 10 and 11: x Contents 5.1.1.3. Hydrolysis ....
Page 12 and 13: Chapter 2 Chemical Stability of Dru
Page 14 and 15: 2.1. • Pathways of Chemical Degra
Page 44 and 45: 2.2. • Factors Affecting Chemical
Page 104 and 105:
2.2. • Factors Affecting Chemical
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
2.2. • Factors Meeting Chemical S
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
23. • Stabilization of Drug Subst
Page 136 and 137:
2.3. • Stabilization of Drug Subs
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
23. • Stabilization of Drug Subst
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
140 Chapter 3 • Physical Stabilit
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
152 Chapter 4 • Stability of Dosa
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
188 Chapter 5 • Stability of Pept
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
Chapter 6 Regulations The efficacy
Page 214 and 215:
6.1. • ICH Harmonised Tripartite
Page 216 and 217:
6.1. • ICH Harmonised Mpartite Gu
Page 218 and 219:
6.1. • ICH Harmonised Trpartite G
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
6.2 • ICH Harmonised Tripartite G
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
5. • Major Concerns Raised by the
Page 232 and 233:
6.3 • Major Concerns Raised by th
Page 234 and 235:
228 References 21. M. L. Maniar, D.
Page 236 and 237:
230 References 71. A. Tsuji, E. Nak
Page 238 and 239:
232 References 121. D. C. Chatteji,
Page 240 and 241:
234 References 173. M. A. F. Hameli
Page 242 and 243:
236 References 222. P. J. G. Comeli
Page 244 and 245:
238 References 270. K. Okazaki, R.
Page 246 and 247:
240 References 327. H. V. Maulding
Page 248 and 249:
242 References 382. H. Zia, M. Teha
Page 250 and 251:
244 References 433. S. Yoshioka and
Page 252 and 253:
246 References 484. M. E. Moro, J.
Page 254 and 255:
248 References 532. E. Pop, T. Loft
Page 256 and 257:
250 References 578. T. Yokoyama, N.
Page 258 and 259:
252 References 628. M. Angberg, C.
Page 260 and 261:
254 References 679. J. T. Rubino, L
Page 262 and 263:
256 References 727. J. H. Wood and
Page 264 and 265:
258 References 779. I. Matsuura and
Page 266 and 267:
260 References 830. D. J. Kroon, A.
Page 268 and 269:
262 References 879. S. Yoshioka, K.
Page 270 and 271:
264 Index Bromovalerylurea, 146, 14
Page 272 and 273:
266 Index Hydrolysis (cont.) Lacton
Page 274:
268 Index Shelf life ( cont.) Table
show all

Stability of Drugs and Dosage Forms Sumie Yoshioka

Create successful ePaper yourself

Delete template?

Save as template?