in vivo

Research Unit for
Immunoinformatics
An important mission of our research
unit is to develop and maintain an open
resource bioinformatics platform and data
resources in order to gain insights into primary
immunodeficiency diseases (PID) through
the accumulation and analysis of genomic,
transcriptomic, and proteomic data. Our
ultimate goal is to provide relevant, up-to-date
and validated information on PID as per global
community standards in an easily decipherable
and usable format.
Unit leader
Sujatha Mohan
Research Associates
: Shivakumar Keerthikumar
Rajesh Raju
Generation of Primary Immunodeficiency
Disease Database from Asia
Primary immunodeficiency diseases are
rare and genetically heterogeneous group of
disorders affecting various components of the
innate and adaptive immune systems. Despite
rapid developments in the science of PID, early
diagnosis and effective treatment of PID have
posed new challenges to physicians all over the
world. In this milieu, the development of a freely
accessible dynamic web-based integrated tool
on PID has become a paramount need of different
target groups such as clinical immunologists,
researchers, patients and family members.
We hope that this initiative will assist
clinical immunologists and physicians in the
identification of susceptible populations followed
by cost effective regular screening procedures
in order to minimize clinical deterioration and
provide researchers with essential clues to
analyze candidate PID genes. We also hope to
create awareness among PID patients to help
them lead a near normal quality of life and to
support affected family members with relevant
PID information.
The strength of this project is that it makes
access to biological information simple for
those without any bioinformatics knowledge
and integrates it with experimental data from a
diverse set of biological platforms including FACS
and DNA genotyping to clinical phenotypes and
signaling pathways. Our first focus is on the
analysis of primary immunodeficiency diseases
because RCAI investigators have been working
intensively on PID in collaboration with outside
researchers and have accumulated a wide array
of clinical and experimental data..
To achieve our goals, we propose to carry
out strategic approaches such as: i) curation
of PID literature information along with publicly
available clinical information into a web accessible
knowledge base, ii) development of PID
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