ISNVD Abstract Book

Background
Iron deposition in clinically isolated syndrome
Jesper Hagemeier 1 , Bianca Weinstock-Guttman 2 , Niels Bergsland 1 , Mari Heininen-Brown 1 , Ellen Carl 1 , Cheryl Kennedy 1 ,
Christopher Magnano 1 , David Hojnacki 2 , Michael G. Dwyer 1 , Robert Zivadinov 1,2
1
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA;
2
The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
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Methods
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Table 1. Demographic, clinical and MRI characteristics
of the study groups.
Legend: HC = healthy controls; CIS = clinically isolated syndrome;
SD = standard deviation; EDSS = Expanded Disability Status Scale;
NGMV = normalized gray matter volume; NWMV = normalized
white matter volume; NBV = normalized brain volume; NLVV =
normalized lateral ventricular volume; NA = not available
All lesion and brain volumes are expressed in milliliters. Of the 42
CIS patients, 33 presented with brain T2 lesions and 9 with spinal
cord T2 lesions.
Differences between the groups were tested using the chi-square
(gender) test and Student’s t-test.
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Results
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Table 2. Differences in the subcortical deep
gray-matter mean phase of abnormal phase tissue
(MP-ATP) between clinically isolated syndrome
patients and healthy controls.
Legend: CIS = clinically isolated syndrome; HC = healthy controls;
SDGM = subcortical deep gray matter; SD = standard deviation;
d = effect size
MP-APT is expressed in radians.
Differences between groups were tested using the Mann-Whitney U test.
Table 3. Differences in the volume of mean phase of
abnormal phase tissue volume (MP-ATP) between
clinically isolated syndrome patients and
healthy controls.
Legend: CIS = clinically isolated syndrome; HC = healthy controls;
SDGM = subcortical deep gray matter; SD = standard deviation;
d = effect size
All volumes are reported in milliliters.
Differences between groups were tested using the
Mann-Whitney U test.
Table 4. Differences in the subcortical deep gray-matter
normalized volumes between clinically isolated syndrome
patients and healthy controls.
Legend: CIS = clinically isolated syndrome; HC = healthy controls;
SDGM = subcortical deep gray matter; SD = standard deviation; d =
effect size
All volumes are reported in milliliters.
Differences between groups were tested using the student t-test.
Conclusions
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References
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