ISNVD Abstract Book
ISNVD Abstract Book
ISNVD Abstract Book
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Iron deposition in pediatric multiple sclerosis patients<br />
Jesper Hagemeier 1 , E. Ann Yeh, Mari Heininen Brown 1 , Niels Bergsland 1 , Michael G. Dwyer, 1 ,<br />
Ellen Carl 1 , Bianca Weinstock-Guttman 2 , Robert Zivadinov 1,2<br />
1 Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA; 2 The Jacobs<br />
Neurological Institute, University at Buffalo, Buffalo, NY, USA<br />
<strong>Abstract</strong><br />
Background: The extent of iron deposition in the subcortical deep gray matter (SDGM) has<br />
been extensively investigated in adult but not in pediatric multiple sclerosis (MS) patients.<br />
Objective: To assess abnormal phase values, indicative of increased iron content, using<br />
susceptibility-weighted imaging (SWI)-filtered phase of the SDGM in pediatric MS patients and<br />
healthy controls (HC).<br />
Methods: Twenty (20) pediatric MS patients (11 female, 9 male) and 21 age- and sex-matched<br />
HC (10 female, 11 male) were scanned on a 3T GE scanner. Mean age was 15.6 (SD=2.9) years<br />
in patients, and 14.8 (SD=3) years in HC. Mean phase of the abnormal phase tissue (MP-APT),<br />
normal phase tissue volume (NPTV) and normalized volume measurements were derived for<br />
total SDGM, as well as specific structures separately. The study was approved by local<br />
Institutional Review Board and all participants provided written informed consent.<br />
Results: Significantly increased MP-APT (28.2%, p
Change language