ISNVD Abstract Book

Iron deposition in pediatric multiple sclerosis patients
Jesper Hagemeier 1 , E. Ann Yeh 2 , Mari Heininen-Brown 1 , Niels Bergsland 1 , Michael G. Dwyer 1 , Ellen Carl 1 ,
Bianca Weinstock-Guttman 2 , Robert Zivadinov 1,2
1
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA;
2
The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
Background
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Methods
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Table 1. Clinical and demographic characteristics of
healthy control subjects and pediatric MS patients.
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Legend: HC = healthy controls, MS = multiple sclerosis
Volume measurements are expressed in cubic millimeters.
Differences between groups in demographic characteristics and
atrophy measures were tested using the independent samples
Student’s t-test and chi-squared test.
Figure. Individual susceptibility-weighted
with the MNI atlas and then averaged together
to create mean phase images for 21 healthy
controls (left) and 20 MS patients (right).
The pulvinar nucleus of thalamus (arrow) appears
bilaterally brighter in the MS group image,
and corresponds to our mean phase of the
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Results
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Table 2. Mean phase of the abnormal phase tissue
(MP-APT) measurements of subcortical deep gray
matter structures of healthy control subjects and
pediatric MS patients.
Legend: MP-APT = mean phase of the abnormal phase tissue,
MS = multiple sclerosis, HC = healthy controls; SDGM = subcortical
deep gray matter
MP-APT is expressed in radians. Differences between groups were
tested using the Mann-Whitney U test.
Table 3. Volume measurements of subcortical deep
gray matter structures of healthy control subjects
and pediatric MS patients.
Conclusions
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References
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Legend: MS = multiple sclerosis, HC = healthy controls
All normalized deep gray matter volumes are expressed in
using the Student’s t-test.