ISNVD Abstract Book

The motivation for this protocol of course comes from the major thrust today from Dr. Zamboni’s
work that there is an association of abnormal venous flow in patients with MS. However, the CCSVI
protocol now provides a new means by which to compare flow abnormalities with patient’s status,
the number of lesions and flow deficits to the brain, for example. Other comparisons can be done
with iron content in the form of transferring, ferritin and hemosiderin. Still other tests could be done
comparing the flow abnormalities with genetic defects or gene association. The usual comparisons
with lesion load and EDSS or MSIS-29 could also be performed.
The other issue comes in training neuroradiologists and neurologists how to read images showing either
abnormal vascular anatomy or interpreting what is normal flow and what is abnormal flow. Training may
need to involve understanding the technical limitations of these methods as well.
MRI PROTOCOL 1: THE FULL PROTOCOL WITHOUT CONTRAST
BODY OF VENDOR MRI ACRONYMS
TIME OF
MRI SEQUENCE
EXAMINATION Siemens GE Philips
AQUISITION
SWI/MRA GRE GRE SWI - 1 x 0.5 x 2 mm 3 07:28
T2 T2 T2 T2 02:30
HEAD
SWI/MRA GRE GRE SWI - 0.5 x 0.5 x 1.0 mm 3 07:28
FLAIR FLAIR FLAIR FLAIR-SAG 05:20
DTI DTI DTI 2 x 2 x 2 mm 3 - 30 Directions 06:50
ASL ASL ASL 3 x 3 x 3 mm 3 04:44
3-D
MPRAGE Fast 3D TFE MPRAGE 04:03
SPGR
Move the table center at the NECK
T2 T2 T2 T2-SAG 02:22
TOF TOF TOF 2D TOF MRV 06:57
NECK
FLOW QUANTIFICATION AT CSF AND
FQ FQ FQ
01:42 (x5)
THREE NECK LEVELS
Total Scan Time: roughly 57 minutes
MRI PROTOCOL 1: PARTIAL HEAD ONLY PROTOCOL WITHOUT CONTRAST
BODY OF VENDOR MRI ACRONYMS
TIME OF
MRI SEQUENCE
EXAMINATION Siemens GE Philips
AQUISITION
SWI/MRA GRE GRE SWI - 1 x 0.5 x 2 mm 3 03:44
T2 T2 T2 T2 02:30
HEAD
SWI/MRA GRE GRE SWI - 0.5 x 0.5 x 1.0 mm 3 07:28
FLAIR FLAIR FLAIR FLAIR-SAG 05:20
DTI DTI DTI 2 x 2 x 2 mm 3 - 30 Directions 06:50
3-D
MPRAGE Fast 3D TFE MPRAGE 04:03
SPGR
Total Scan Time: roughly 30 minutes
TOTAL
TIME
38:23m
17:49m
TOTAL
TIME
29:55m